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X Demographics
Mendeley readers
Attention Score in Context
| Title |
LPS-Challenged Macrophages Release Microvesicles Coated With Histones
|
|---|---|
| Published in |
Frontiers in immunology, June 2018
|
| DOI | 10.3389/fimmu.2018.01463 |
| Pubmed ID | |
| Authors |
Rohini Ravindran Nair, Davide Mazza, Francesca Brambilla, Andrea Gorzanelli, Alessandra Agresti, Marco E. Bianchi |
| Abstract |
Histones are the protein component of nucleosomes, which are the basic packing unit of chromatin. However, histones are also found in the blood, both as components of nucleosomes leaked out from dead cells, or expelled from neutrophils in the active process of NET formation. Circulating histones contribute to inflammation, and to lethality in sepsis, a hyperinflammatory condition, by interacting with specific receptors, notably toll-like receptor 4 (TLR4). Here, we show that histones are also actively released by LPS-activated macrophages in association with extracellular vesicles. Vesicle-associated histones can be recovered from the plasma of mice with sepsis. Actively released histones are on the outer surface of vesicles and can interact with TLR4. Thus, activated macrophages release histones without dying, at the same time, making their DNA more accessible and communicating to other cells that infection is present. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 2 | 29% |
| France | 1 | 14% |
| Unknown | 4 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 84 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 20% |
| Student > Bachelor | 12 | 14% |
| Student > Doctoral Student | 6 | 7% |
| Researcher | 6 | 7% |
| Student > Postgraduate | 6 | 7% |
| Other | 8 | 10% |
| Unknown | 29 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 25 | 30% |
| Agricultural and Biological Sciences | 8 | 10% |
| Immunology and Microbiology | 8 | 10% |
| Medicine and Dentistry | 5 | 6% |
| Chemistry | 3 | 4% |
| Other | 5 | 6% |
| Unknown | 30 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2022.
All research outputs
#8,190,103
of 25,385,509 outputs
Outputs from Frontiers in immunology
#9,922
of 31,537 outputs
Outputs of similar age
#131,474
of 342,755 outputs
Outputs of similar age from Frontiers in immunology
#295
of 727 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 31,537 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,755 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 727 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.