Title |
CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions
|
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Published in |
Frontiers in immunology, July 2018
|
DOI | 10.3389/fimmu.2018.01593 |
Pubmed ID | |
Authors |
Stephanie A. Amici, Nicholas A. Young, Janiret Narvaez-Miranda, Kyle A. Jablonski, Jesus Arcos, Lucia Rosas, Tracey L. Papenfuss, Jordi B. Torrelles, Wael N. Jarjour, Mireia Guerau-de-Arellano |
Abstract |
Macrophages and their monocyte precursors mediate innate immune responses and can promote a spectrum of phenotypes from pro-inflammatory to pro-resolving. Currently, there are few markers that allow for robust dissection of macrophage phenotype. We recently identified CD38 as a marker of inflammatory macrophages in murine in vitro and in vivo models. However, it is unknown whether CD38 plays a similar marker and/or functional role in human macrophages and inflammatory diseases. Here, we establish that CD38 transcript and protein are robustly induced in human macrophages exposed to LPS (±IFN-γ) inflammatory stimuli, but not with the alternative stimulus, IL-4. Pharmacologic and/or genetic CD38 loss-of-function significantly reduced the secretion of inflammatory cytokines IL-6 and IL-12p40 and glycolytic activity in human primary macrophages. Finally, monocyte analyses in systemic lupus erythematosus patients revealed that, while all monocytes express CD38, high CD38 expression in the non-classical monocyte subpopulation is associated with disease. These data are consistent with an inflammatory marker role for CD38 in human macrophages and monocytes. |
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