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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Role of Tissue-Resident Memory in Intra-Tumor Heterogeneity and Response to Immune Checkpoint Blockade
|
|---|---|
| Published in |
Frontiers in immunology, July 2018
|
| DOI | 10.3389/fimmu.2018.01655 |
| Pubmed ID | |
| Authors |
Kavita M. Dhodapkar |
| Abstract |
Tissue-resident memory T (TRM) cells are a distinct subset of memory T cells that reside in non-lymphoid tissues for prolonged periods of time without significant recirculation providing continued immune surveillance at these sites. Recent studies suggest that TRM cells are also enriched within tumor tissue. Expression of inhibitory immune checkpoints (ICPs) is particularly enriched on this subset of tumor-infiltrating T cells, suggesting that they are major targets for newer therapies targeting ICPs such as the programmed death-1 pathway. Recent studies suggest that tissue restriction of these cells without recirculation may also lead to heterogeneity of TRM cells within individual metastatic lesions, ultimately leading to inter-lesional diversity. Thus, individual metastatic lesions may contain genomically distinct immune microenvironments that impact both evolution of tumors as well as the mechanisms underlying response and resistance to immune therapies. Understanding the biology of TRM cells infiltrating tumors will be essential to improving immune-based approaches in diverse settings. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 2 | 15% |
| United States | 2 | 15% |
| Malaysia | 1 | 8% |
| India | 1 | 8% |
| Venezuela, Bolivarian Republic of | 1 | 8% |
| Sweden | 1 | 8% |
| Japan | 1 | 8% |
| Switzerland | 1 | 8% |
| Unknown | 3 | 23% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 69% |
| Scientists | 3 | 23% |
| Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 21% |
| Researcher | 4 | 12% |
| Student > Master | 4 | 12% |
| Professor | 2 | 6% |
| Professor > Associate Professor | 2 | 6% |
| Other | 5 | 15% |
| Unknown | 9 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 12 | 36% |
| Medicine and Dentistry | 8 | 24% |
| Agricultural and Biological Sciences | 1 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Social Sciences | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 9 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2018.
All research outputs
#5,527,395
of 25,663,438 outputs
Outputs from Frontiers in immunology
#6,296
of 32,156 outputs
Outputs of similar age
#96,245
of 340,400 outputs
Outputs of similar age from Frontiers in immunology
#185
of 676 outputs
Altmetric has tracked 25,663,438 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32,156 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,400 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 676 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.