The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Vitamin B1 Helps to Limit Mycobacterium tuberculosis Growth via Regulating Innate Immunity in a Peroxisome Proliferator-Activated Receptor-γ-Dependent Manner
|
|---|---|
| Published in |
Frontiers in immunology, August 2018
|
| DOI | 10.3389/fimmu.2018.01778 |
| Pubmed ID | |
| Authors |
Shengfeng Hu, Wenting He, Xialin Du, Yulan Huang, Yuling Fu, Yalong Yang, Chuxuan Hu, Silin Li, Qinshu Wang, Qian Wen, Xinying Zhou, Chaoying Zhou, Xiao-Ping Zhong, Li Ma |
| Abstract |
It is known that vitamin B1 (VB1) has a protective effect against oxidative retinal damage induced by anti-tuberculosis drugs. However, it remains unclear whether VB1 regulates immune responses during Mycobacterium tuberculosis (MTB) infection. We report here that VB1 promotes the protective immune response to limit the survival of MTB within macrophages and in vivo through regulation of peroxisome proliferator-activated receptor γ (PPAR-γ). VB1 promotes macrophage polarization into classically activated phenotypes with strong microbicidal activity and enhanced tumor necrosis factor-α and interleukin-6 expression at least in part by promoting nuclear factor-κB signaling. In addition, VB1 increases mitochondrial respiration and lipid metabolism and PPAR-γ integrates the metabolic and inflammatory signals regulated by VB1. Using both PPAR-γ agonists and deficient mice, we demonstrate that VB1 enhances anti-MTB activities in macrophages and in vivo by down-regulating PPAR-γ activity. Our data demonstrate important functions of VB1 in regulating innate immune responses against MTB and reveal novel mechanisms by which VB1 exerts its function in macrophages. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 12% |
| Turkey | 1 | 6% |
| Australia | 1 | 6% |
| Malaysia | 1 | 6% |
| Unknown | 12 | 71% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 88% |
| Scientists | 2 | 12% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 57 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 14% |
| Student > Bachelor | 6 | 11% |
| Researcher | 6 | 11% |
| Student > Ph. D. Student | 4 | 7% |
| Other | 3 | 5% |
| Other | 4 | 7% |
| Unknown | 26 | 46% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 16% |
| Biochemistry, Genetics and Molecular Biology | 7 | 12% |
| Immunology and Microbiology | 5 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
| Social Sciences | 3 | 5% |
| Other | 5 | 9% |
| Unknown | 24 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2024.
All research outputs
#2,391,092
of 26,430,863 outputs
Outputs from Frontiers in immunology
#2,402
of 33,201 outputs
Outputs of similar age
#43,717
of 328,633 outputs
Outputs of similar age from Frontiers in immunology
#67
of 617 outputs
Altmetric has tracked 26,430,863 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 33,201 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,633 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 617 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.