Title |
Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions
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Published in |
Frontiers in immunology, August 2018
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DOI | 10.3389/fimmu.2018.01792 |
Pubmed ID | |
Authors |
Nicolas Fazilleau, Meryem Aloulou |
Abstract |
An efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to be the negative regulators. Indeed, Tfr cells are considered as a homogenous cell population dedicated to dampen the GC extent. Moreover, Tfr cells prevent autoimmunity since their dysregulation leads to production of self-reactive antibodies (Ab). However, a growing corpus of evidence has revealed additional and unexpected functions for Tfr cells in the regulation of B cell responses. This review provides an overview of the Tfr cell contribution and presents Tfr cell proprieties in the context of vaccination. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 67 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 24% |
Researcher | 12 | 18% |
Student > Bachelor | 7 | 10% |
Student > Master | 7 | 10% |
Student > Postgraduate | 3 | 4% |
Other | 8 | 12% |
Unknown | 14 | 21% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 24 | 36% |
Biochemistry, Genetics and Molecular Biology | 9 | 13% |
Medicine and Dentistry | 9 | 13% |
Agricultural and Biological Sciences | 5 | 7% |
Mathematics | 1 | 1% |
Other | 4 | 6% |
Unknown | 15 | 22% |