Title |
Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer
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Published in |
Frontiers in immunology, September 2018
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DOI | 10.3389/fimmu.2018.02030 |
Pubmed ID | |
Authors |
Sayeda Yasmin-Karim, Patrick T. Bruck, Michele Moreau, Sijumon Kunjachan, Gui Zhen Chen, Rajiv Kumar, Stephanie Grabow, Stephanie K. Dougan, Wilfred Ngwa |
Abstract |
Radiation therapy induces immunogenic cell death, which can theoretically stimulate T cell priming and induction of tumor-specific memory T cell responses, serving as an in situ vaccine. In practice, this abscopal effect is rarely observed. We use two mouse models of pancreatic cancer to show that a single dose of stereotactic body radiation therapy (SBRT) synergizes with intratumoral injection of agonistic anti-CD40, resulting in regression of non-treated contralateral tumors and formation of long-term immunologic memory. Long-term survival was not observed when mice received multiple fractions of SBRT, or when TGFβ blockade was combined with SBRT. SBRT and anti-CD40 was so effective at augmenting T cell priming, that memory CD8 T cell responses to both tumor and self-antigens were induced, resulting in vitiligo in long-term survivors. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Switzerland | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 91 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 14 | 15% |
Student > Ph. D. Student | 12 | 13% |
Student > Doctoral Student | 10 | 11% |
Student > Master | 8 | 9% |
Other | 7 | 8% |
Other | 15 | 16% |
Unknown | 25 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 22 | 24% |
Biochemistry, Genetics and Molecular Biology | 12 | 13% |
Immunology and Microbiology | 10 | 11% |
Agricultural and Biological Sciences | 6 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 9 | 10% |
Unknown | 29 | 32% |