Title |
Insight Into Inflammasome Signaling: Implications for Toxoplasma gondii Infection
|
---|---|
Published in |
Frontiers in immunology, December 2020
|
DOI | 10.3389/fimmu.2020.583193 |
Pubmed ID | |
Authors |
Yang Wang, Jinjin Zhu, Yuanyuan Cao, Jilong Shen, Li Yu |
Abstract |
Inflammasomes are multimeric protein complexes regulating the innate immune response to invading pathogens or stress stimuli. Recent studies have reported that nucleotide-binding leucine-rich repeat-containing (NLRs) proteins and DNA sensor absent in melanoma 2 (AIM2) serve as inflammasome sentinels, whose stimulation leads to the proteolytic activation of caspase-1, proinflammatory cytokine secretion, and pyroptotic cell death. Toxoplasma gondii, an obligate intracellular parasite of phylum Apicomplexans, is reportedly involved in NLRP1, NLRP3 and AIM2 inflammasomes activation; however, mechanistic evidence regarding the activation of these complexes is preliminary. This review describes the current understanding of inflammasome signaling in rodent and human models of T. gondii infection. |
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Country | Count | As % |
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Canada | 1 | 20% |
United States | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
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Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 6 | 21% |
Student > Bachelor | 4 | 14% |
Student > Ph. D. Student | 2 | 7% |
Student > Postgraduate | 2 | 7% |
Other | 1 | 3% |
Other | 2 | 7% |
Unknown | 12 | 41% |
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Agricultural and Biological Sciences | 1 | 3% |
Other | 3 | 10% |
Unknown | 13 | 45% |