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Insight Into Inflammasome Signaling: Implications for Toxoplasma gondii Infection

Overview of attention for article published in Frontiers in immunology, December 2020
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

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Title
Insight Into Inflammasome Signaling: Implications for Toxoplasma gondii Infection
Published in
Frontiers in immunology, December 2020
DOI 10.3389/fimmu.2020.583193
Pubmed ID
Authors

Yang Wang, Jinjin Zhu, Yuanyuan Cao, Jilong Shen, Li Yu

Abstract

Inflammasomes are multimeric protein complexes regulating the innate immune response to invading pathogens or stress stimuli. Recent studies have reported that nucleotide-binding leucine-rich repeat-containing (NLRs) proteins and DNA sensor absent in melanoma 2 (AIM2) serve as inflammasome sentinels, whose stimulation leads to the proteolytic activation of caspase-1, proinflammatory cytokine secretion, and pyroptotic cell death. Toxoplasma gondii, an obligate intracellular parasite of phylum Apicomplexans, is reportedly involved in NLRP1, NLRP3 and AIM2 inflammasomes activation; however, mechanistic evidence regarding the activation of these complexes is preliminary. This review describes the current understanding of inflammasome signaling in rodent and human models of T. gondii infection.

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X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 6 21%
Student > Bachelor 4 14%
Student > Ph. D. Student 2 7%
Student > Postgraduate 2 7%
Other 1 3%
Other 2 7%
Unknown 12 41%
Readers by discipline Count As %
Immunology and Microbiology 5 17%
Biochemistry, Genetics and Molecular Biology 4 14%
Neuroscience 2 7%
Unspecified 1 3%
Agricultural and Biological Sciences 1 3%
Other 3 10%
Unknown 13 45%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2021.
All research outputs
#14,399,152
of 25,387,668 outputs
Outputs from Frontiers in immunology
#11,654
of 31,541 outputs
Outputs of similar age
#239,559
of 518,109 outputs
Outputs of similar age from Frontiers in immunology
#317
of 723 outputs
Altmetric has tracked 25,387,668 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,541 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 518,109 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 723 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.