Title |
Gastrointestinal Stromal Tumor – An Evolving Concept
|
---|---|
Published in |
Frontiers in Medicine, November 2014
|
DOI | 10.3389/fmed.2014.00043 |
Pubmed ID | |
Authors |
Luigi Tornillo |
Abstract |
Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal tumors of the gastrointestinal tract. The discovery that these tumors, formerly thought of smooth muscle origin, are indeed better characterized by specific activating mutation in genes coding for the receptor tyrosine kinases (RTKs) CKIT and PDGFRA and that these mutations are strongly predictive for the response to targeted therapy with RTK inhibitors has made GISTs the typical example of the integration of basic molecular knowledge in the daily clinical activity. The information on the mutational status of these tumors is essential to predict (and subsequently to plan) the therapy. As resistant cases are frequently wild type, other possible oncogenic events, defining other "entities," have been discovered (e.g., succinil dehydrogenase mutation/dysregulation, insuline growth factor expression, and mutations in the RAS-RAF-MAPK pathway). The classification of disease must nowadays rely on the integration of the clinico-morphological characteristics with the molecular data. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Luxembourg | 1 | 4% |
Belgium | 1 | 4% |
Unknown | 22 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 4 | 17% |
Student > Postgraduate | 4 | 17% |
Student > Master | 3 | 13% |
Student > Ph. D. Student | 3 | 13% |
Researcher | 3 | 13% |
Other | 3 | 13% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 42% |
Agricultural and Biological Sciences | 4 | 17% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Immunology and Microbiology | 1 | 4% |
Design | 1 | 4% |
Other | 0 | 0% |
Unknown | 6 | 25% |