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The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease

Overview of attention for article published in Frontiers in Medicine, August 2017
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Title
The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease
Published in
Frontiers in Medicine, August 2017
DOI 10.3389/fmed.2017.00126
Pubmed ID
Authors

Renata Curciarello, Guillermo H. Docena, Thomas T. MacDonald

Abstract

Crohn's disease is an idiopathic disorder of the gut thought to be caused by a combination of environmental and genetic factors in susceptible individuals. It is characterized by chronic transmural inflammation of the terminal ileum and colon, with typical transmural lesions. Complications, including fibrosis, mean that between 40 and 70% of patients require surgery in the first 10 years after diagnosis. Presently, there is no evidence that the current therapies which dampen inflammation modulate or reverse intestinal fibrosis. In this review, we focus on cytokines that may lead to fibrosis and stenosis and the contribution of experimental models for understanding and treatment of gut fibrosis.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 13%
Student > Doctoral Student 6 11%
Student > Bachelor 6 11%
Student > Ph. D. Student 6 11%
Student > Postgraduate 5 9%
Other 8 15%
Unknown 16 30%
Readers by discipline Count As %
Medicine and Dentistry 18 33%
Pharmacology, Toxicology and Pharmaceutical Science 5 9%
Agricultural and Biological Sciences 5 9%
Biochemistry, Genetics and Molecular Biology 4 7%
Immunology and Microbiology 3 6%
Other 2 4%
Unknown 17 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2017.
All research outputs
#15,474,679
of 22,996,001 outputs
Outputs from Frontiers in Medicine
#3,043
of 5,763 outputs
Outputs of similar age
#199,319
of 317,751 outputs
Outputs of similar age from Frontiers in Medicine
#38
of 63 outputs
Altmetric has tracked 22,996,001 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,763 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.4. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,751 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.