The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Transfusion-Transmitted Hepatitis E: NAT Screening of Blood Donations and Infectious Dose
|
|---|---|
| Published in |
Frontiers in Medicine, February 2018
|
| DOI | 10.3389/fmed.2018.00005 |
| Pubmed ID | |
| Authors |
Jens Dreier, Cornelius Knabbe, Tanja Vollmer |
| Abstract |
The risk and importance of transfusion-transmitted hepatitis E virus (TT-HEV) infections by contaminated blood products is currently a controversial discussed topic in transfusion medicine. The infectious dose, in particular, remains an unknown quantity. In the present study, we illuminate and review this aspect seen from the viewpoint of a blood donation service with more than 2 years of experience in routine HEV blood donor screening. We systematically review the actual status of presently known cases of TT-HEV infections and available routine NAT-screening assays. The review of the literature revealed a significant variation regarding the infectious dose causing hepatitis E. We also present the outcome of six cases confronted with HEV-contaminated blood products, identified by routine HEV RNA screening of minipools using the highly sensitive RealStar HEV RT-PCR Kit (95% LOD: 4.7 IU/mL). Finally, the distribution of viral RNA in different blood components [plasma, red blood cell concentrate (RBC), platelet concentrates (PC)] was quantified using the first WHO international standard for HEV RNA for NAT-based assays. None of the six patients receiving an HEV-contaminated blood product from five different donors (donor 1: RBC, donor 2-5: APC) developed an acute hepatitis E infection, most likely due to low viral load in donor plasma (<100 IU/mL). Of note, the distribution of viral RNA in blood components depends on the plasma content of the component; nonetheless, HEV RNA could be detected in RBCs even when low viral plasma loads of 100-1,000 IU/mL are present. Comprehensive retrospective studies of TT-HEV infection offered further insights into the infectivity of HEV RNA-positive blood products. Minipool HEV NAT screening (96 samples) of blood donations should be adequate as a routine screening assay to identify high viremic donors and will cover at least a large part of viremic phases. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 1 | 4% |
| Somalia | 1 | 4% |
| American Samoa | 1 | 4% |
| South Africa | 1 | 4% |
| Brazil | 1 | 4% |
| Nigeria | 1 | 4% |
| India | 1 | 4% |
| Switzerland | 1 | 4% |
| Germany | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 14 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 72% |
| Scientists | 5 | 20% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 48 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 15% |
| Researcher | 6 | 13% |
| Student > Bachelor | 5 | 10% |
| Other | 2 | 4% |
| Student > Master | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 21 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 17% |
| Immunology and Microbiology | 7 | 15% |
| Medicine and Dentistry | 4 | 8% |
| Veterinary Science and Veterinary Medicine | 2 | 4% |
| Environmental Science | 1 | 2% |
| Other | 4 | 8% |
| Unknown | 22 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2023.
All research outputs
#1,888,590
of 26,383,519 outputs
Outputs from Frontiers in Medicine
#545
of 7,533 outputs
Outputs of similar age
#41,911
of 454,941 outputs
Outputs of similar age from Frontiers in Medicine
#11
of 102 outputs
Altmetric has tracked 26,383,519 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,533 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.7. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 454,941 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 102 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.