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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Emerging Mechanisms of Innate Immunity and Their Translational Potential in Inflammatory Bowel Disease
|
|---|---|
| Published in |
Frontiers in Medicine, February 2018
|
| DOI | 10.3389/fmed.2018.00032 |
| Pubmed ID | |
| Authors |
Daniele Corridoni, Thomas Chapman, Tim Ambrose, Alison Simmons |
| Abstract |
Activation of the innate immune system through pattern-recognition receptor (PRR) signaling plays a pivotal role in the early induction of host defense following exposure to pathogens. Loss of intestinal innate immune regulation leading aberrant immune responses has been implicated in the pathogenesis of inflammatory bowel disease (IBD). The precise role of PRRs in gut inflammation is not well understood, but considering their role as bacterial sensors and their genetic association with IBD, they likely contribute to dysregulated immune responses to the commensal microbiota. The purpose of this review is to evaluate the emerging functions of PRRs including their functional cross-talk, how they respond to mitochondrial damage, induce mitophagy or autophagy, and influence adaptive immune responses by interacting with the antigen presentation machinery. The review also summarizes some of the recent attempts to harness these pathways for therapeutic approaches in intestinal inflammation. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 30% |
| Unknown | 7 | 70% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 80% |
| Scientists | 2 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 76 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 20% |
| Student > Ph. D. Student | 12 | 16% |
| Student > Bachelor | 9 | 12% |
| Student > Master | 6 | 8% |
| Other | 5 | 7% |
| Other | 8 | 11% |
| Unknown | 21 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 21% |
| Medicine and Dentistry | 15 | 20% |
| Immunology and Microbiology | 7 | 9% |
| Agricultural and Biological Sciences | 7 | 9% |
| Nursing and Health Professions | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 23 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2020.
All research outputs
#2,968,717
of 26,184,649 outputs
Outputs from Frontiers in Medicine
#878
of 7,430 outputs
Outputs of similar age
#58,782
of 347,981 outputs
Outputs of similar age from Frontiers in Medicine
#19
of 105 outputs
Altmetric has tracked 26,184,649 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,430 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.1. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 347,981 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 105 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.