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Multimodal Imaging-Based Phenotyping of a Singaporean Hospital-Based Cohort of High Myopia Patients

Overview of attention for article published in Frontiers in Medicine, January 2022
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Title
Multimodal Imaging-Based Phenotyping of a Singaporean Hospital-Based Cohort of High Myopia Patients
Published in
Frontiers in Medicine, January 2022
DOI 10.3389/fmed.2021.670229
Pubmed ID
Authors

Kai Yuan Tey, Quan V. Hoang, Isabella Q. Loh, Yee Shan Dan, Qiu Ying Wong, Daryle Jason G. Yu, Vivi R. Yandri, Marcus Ang, Gemmy C. M. Cheung, Shu Yen Lee, Tien Yin Wong, SNEC Retina Group, Rachel S. Chong, Chee Wai Wong, Anna Cheng, Sim Tan, Beau James Fenner, Choi Mun Chan, Ian Yew San Yeo, Kelvin Yi Chong Teo, Ranjana Mathur, Shaun Sebastian Sim, Wiryasaputra Shaan, Andrew Shih Hsiang Tsai, Chong Lye Ang, Ning Cheung, Ting Shu Wei Daniel, Doric Wen Kuan Wong, Edmund Yick Mun Wong, Gavin Siew Wei Tan, Hyungtaek Rim

Abstract

Purpose: To assess the effect of axial length (AL) on the prevalence of pathologic myopia (PM) and associated myopic features in a Singaporean hospital-based cohort of patient with high myopia (HM). Methods: In total, 923 HM eyes from 495 individuals were recruited from the Myopic and Pathologic Eyes in Singapore (MyoPES) cohort and underwent ocular biometry, fundus photography, fundus autofluorescence, and swept-source optical coherence tomography (SS-OCT). Images were analyzed for the presence of myopic macular degeneration (MMD), myopic choroidal neovascularization (mCNV), myopic traction maculopathy (MTM), peripapillary atrophy (PPA), myopic tilted disc, posterior staphyloma (PS), dome-shaped macula (DSM), vitremacular adhesions (VMA), and the epiretinal membrane (ERM). Eyes were stratified into quartiles based on ALs to determine cut-off values to perform comparisons between shorter-length and longer-length groups. A χ2-test was done to determine the difference in the prevalence of pathologies between groups. Results: Overall, mean AL was 29.2 ± 2.2 mm (range 25.0-36.7 mm). Myopic macular degeneration, PPA, myopic tilted disc, and ERM have AL threshold of ≥27.5 mm, whereas MTM has an AL threshold of ≥29.0 mm. We found that there was a significantly higher prevalence of MMD (88.2 vs. 49.4%; p < 0.001), PPA (98.1 vs. 80.1%; p < 0.001), myopic tilted disc (72.7 vs. 50.2%; p < 0.001), and ERM (81.4 vs. 17.3%; p = 0.003) in eyes with AL ≥ 27.5 mm vs. eyes without AL <27.5 mm. Prevalence of MTM (34.7 vs. 32.1%; p < 0.001), mCNV (17.4 vs. 12.1%; p = 0.03), PS (43.4 vs. 34.7%; p = 0.012), DSM (21.3 vs. 13.2%; p = 0.002), and VMA (5.9 vs. 2.6%; p = 0.014) in eyes with AL ≥ 29.0 mm compared with AL < 29.0 mm. Conclusion: Our study describes the overall prevalence of PM and related pathologies among patients with HM in our hospital-based cohort. Longer eyes even among HM eyes had a significantly higher prevalence of PM-associated pathologies studied. This supports the premise that eyes with longer AL, even among HM eyes may be at greater risk of vision-threatening changes and therefore merit regular follow-up.

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Mendeley readers

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The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Other 1 17%
Student > Master 1 17%
Unknown 4 67%
Readers by discipline Count As %
Medicine and Dentistry 2 33%
Unknown 4 67%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2022.
All research outputs
#15,533,651
of 23,085,832 outputs
Outputs from Frontiers in Medicine
#3,090
of 5,845 outputs
Outputs of similar age
#281,760
of 504,412 outputs
Outputs of similar age from Frontiers in Medicine
#316
of 629 outputs
Altmetric has tracked 23,085,832 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,845 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.4. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 504,412 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 629 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.