Title |
Structures and host-adhesion mechanisms of lactococcal siphophages
|
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Published in |
Frontiers in Microbiology, January 2014
|
DOI | 10.3389/fmicb.2014.00003 |
Pubmed ID | |
Authors |
Silvia Spinelli, David Veesler, Cecilia Bebeacua, Christian Cambillau |
Abstract |
The Siphoviridae family of bacteriophages is the largest viral family on earth and comprises members infecting both bacteria and archaea. Lactococcal siphophages infect the Gram-positive bacterium Lactococcus lactis, which is widely used for industrial milk fermentation processes (e.g., cheese production). As a result, lactococcal phages have become one of the most thoroughly characterized class of phages from a genomic standpoint. They exhibit amazing and intriguing characteristics. First, each phage has a strict specificity toward a unique or a handful of L. lactis host strains. Second, most lactococcal phages possess a large organelle at their tail tip (termed the baseplate), bearing the receptor binding proteins (RBPs) and mediating host adsorption. The recent accumulation of structural and functional data revealed the modular structure of their building blocks, their different mechanisms of activation and the fine specificity of their RBPs. These results also illustrate similarities and differences between lactococcal Siphoviridae and Gram-negative infecting Myoviridae. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Australia | 1 | 1% |
Unknown | 83 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 18% |
Researcher | 14 | 16% |
Student > Bachelor | 14 | 16% |
Student > Master | 11 | 13% |
Student > Doctoral Student | 4 | 5% |
Other | 10 | 12% |
Unknown | 17 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 24 | 28% |
Biochemistry, Genetics and Molecular Biology | 24 | 28% |
Immunology and Microbiology | 6 | 7% |
Engineering | 3 | 4% |
Environmental Science | 2 | 2% |
Other | 8 | 9% |
Unknown | 18 | 21% |