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Antimicrobial photodynamic therapy for inactivation of biofilms formed by oral key pathogens

Overview of attention for article published in Frontiers in Microbiology, August 2014
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Title
Antimicrobial photodynamic therapy for inactivation of biofilms formed by oral key pathogens
Published in
Frontiers in Microbiology, August 2014
DOI 10.3389/fmicb.2014.00405
Pubmed ID
Authors

Fabian Cieplik, Laura Tabenski, Wolfgang Buchalla, Tim Maisch

Abstract

With increasing numbers of antibiotic-resistant pathogens all over the world there is a pressing need for strategies that are capable of inactivating biofilm-state pathogens with less potential of developing resistances in pathogens. Antimicrobial strategies of that kind are especially needed in dentistry in order to avoid the usage of antibiotics for treatment of periodontal, endodontic or mucosal topical infections caused by bacterial or yeast biofilms. One possible option could be the antimicrobial photodynamic therapy (aPDT), whereby the lethal effect of aPDT is based on the principle that visible light activates a photosensitizer (PS), leading to the formation of reactive oxygen species, e.g., singlet oxygen, which induce phototoxicity immediately during illumination. Many compounds have been described as potential PS for aPDT against bacterial and yeast biofilms so far, but conflicting results have been reported. Therefore, the aim of the present review is to outline the actual state of the art regarding the potential of aPDT for inactivation of biofilms formed in vitro with a main focus on those formed by oral key pathogens and structured regarding the distinct types of PS.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 264 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 264 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 46 17%
Student > Ph. D. Student 43 16%
Student > Bachelor 33 13%
Researcher 27 10%
Student > Postgraduate 23 9%
Other 37 14%
Unknown 55 21%
Readers by discipline Count As %
Medicine and Dentistry 74 28%
Chemistry 29 11%
Biochemistry, Genetics and Molecular Biology 27 10%
Immunology and Microbiology 22 8%
Agricultural and Biological Sciences 21 8%
Other 30 11%
Unknown 61 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2014.
All research outputs
#20,235,415
of 22,761,738 outputs
Outputs from Frontiers in Microbiology
#22,246
of 24,645 outputs
Outputs of similar age
#194,278
of 231,114 outputs
Outputs of similar age from Frontiers in Microbiology
#144
of 172 outputs
Altmetric has tracked 22,761,738 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,645 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,114 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 172 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.