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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis
|
|---|---|
| Published in |
Frontiers in Microbiology, October 2014
|
| DOI | 10.3389/fmicb.2014.00517 |
| Pubmed ID | |
| Authors |
Mᵃdel Mar Serra-Vidal, Irene Latorre, Kees L. C. M. Franken, Jéssica Díaz, Maria Luiza de Souza-Galvão, Irma Casas, José Maldonado, Cèlia Milà, Jordi Solsona, M. Ángeles Jimenez-Fuentes, Neus Altet, Alícia Lacoma, Juan Ruiz-Manzano, Vicente Ausina, Cristina Prat, Tom H. M. Ottenhoff, José Domínguez |
| Abstract |
The aim of our work here was to evaluate the immunogenicity of 60 mycobacterial antigens, some of which have not been previously assessed, notably a novel series of in vivo-expressed Mycobacterium tuberculosis (IVE-TB) antigens. We enrolled 505 subjects and separated them in individuals with and without latent tuberculosis infection (LTBI) vs. patients with active tuberculosis (TB). Following an overnight and 7 days stimulation of whole blood with purified recombinant M. tuberculosis antigens, interferon-γ (IFN-γ) levels were determined by ELISA. Several antigens could statistically significantly differentiate the groups of individuals. We obtained promising antigens from all studied antigen groups [dormancy survival regulon (DosR regulon) encoded antigens; resuscitation-promoting factors (Rpf) antigens; IVE-TB antigens; reactivation associated antigens]. Rv1733, which is a probable conserved transmembrane protein encoded in DosR regulon, turned out to be very immunogenic and able to discriminate between the three defined TB status, thus considered a candidate biomarker. Rv2389 and Rv2435n, belonging to Rpf family and IVE-TB group of antigens, respectively, also stood out as LTBI biomarkers. Although more studies are needed to support our findings, the combined use of these antigens would be an interesting approach to TB immunodiagnosis candidates. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 85 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 22% |
| Student > Bachelor | 11 | 13% |
| Student > Ph. D. Student | 9 | 10% |
| Student > Master | 8 | 9% |
| Other | 5 | 6% |
| Other | 14 | 16% |
| Unknown | 21 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 14 | 16% |
| Biochemistry, Genetics and Molecular Biology | 14 | 16% |
| Agricultural and Biological Sciences | 13 | 15% |
| Medicine and Dentistry | 12 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
| Other | 4 | 5% |
| Unknown | 29 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2014.
All research outputs
#18,380,628
of 22,766,595 outputs
Outputs from Frontiers in Microbiology
#19,193
of 24,666 outputs
Outputs of similar age
#182,216
of 255,128 outputs
Outputs of similar age from Frontiers in Microbiology
#127
of 162 outputs
Altmetric has tracked 22,766,595 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,666 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,128 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 162 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.