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Genetic basis of the association of resistance genes mef(I) (macrolides) and catQ (chloramphenicol) in streptococci

Overview of attention for article published in Frontiers in Microbiology, January 2015
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Title
Genetic basis of the association of resistance genes mef(I) (macrolides) and catQ (chloramphenicol) in streptococci
Published in
Frontiers in Microbiology, January 2015
DOI 10.3389/fmicb.2014.00747
Pubmed ID
Authors

Marina Mingoia, Eleonora Morici, Andrea Brenciani, Eleonora Giovanetti, Pietro E. Varaldo

Abstract

In streptococci mef(I) and catQ, two relatively uncommon macrolide and chloramphenicol resistance genes, respectively, are typically linked in a genetic module designated IQ module. Though variable, the module consistently encompasses, and is sometimes reduced to, a conserved ∼5.8-kb mef(I)-catQ fragment. The prototype IQ module was described in Streptococcus pneumoniae. IQ-like modules have subsequently been detected in Streptococcus pyogenes and in different species of viridans group streptococci, where mef(E) may be found instead of mef(I). Three genetic elements, one carrying the prototype IQ module from S. pneumoniae and two carrying different, defective IQ modules from S. pyogenes, have recently been characterized. All are integrative and conjugative elements (ICEs) belonging to the Tn5253 family, and have been designated ICESpn529IQ, ICESpy029IQ and ICESpy005IQ, respectively. ICESpy029IQ and ICESpy005IQ were the first Tn5253 family ICEs to be described in S. pyogenes. A wealth of new information has been obtained by comparing their genetic organization, chromosomal integration, and transferability. The origin of the IQ module is unknown. The mechanism by which it spreads in streptococci is discussed.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 6 18%
Student > Master 5 15%
Student > Bachelor 4 12%
Researcher 4 12%
Student > Ph. D. Student 3 9%
Other 7 21%
Unknown 5 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 26%
Agricultural and Biological Sciences 7 21%
Pharmacology, Toxicology and Pharmaceutical Science 3 9%
Medicine and Dentistry 3 9%
Computer Science 1 3%
Other 2 6%
Unknown 9 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2015.
All research outputs
#17,736,409
of 22,776,824 outputs
Outputs from Frontiers in Microbiology
#17,088
of 24,689 outputs
Outputs of similar age
#241,497
of 352,325 outputs
Outputs of similar age from Frontiers in Microbiology
#187
of 272 outputs
Altmetric has tracked 22,776,824 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,689 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,325 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 272 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.