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Post-translational modification of PII signal transduction proteins

Overview of attention for article published in Frontiers in Microbiology, January 2015
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Title
Post-translational modification of PII signal transduction proteins
Published in
Frontiers in Microbiology, January 2015
DOI 10.3389/fmicb.2014.00763
Pubmed ID
Authors

Mike Merrick

Abstract

The PII proteins constitute one of the most widely distributed families of signal transduction proteins in nature. They are pivotal players in the control of nitrogen metabolism in bacteria and archaea, and are also found in the plastids of plants. Quite remarkably PII proteins control the activities of a diverse range of enzymes, transcription factors and membrane transport proteins, and in all known cases they achieve their regulatory effect by direct interaction with their target. PII proteins in the Proteobacteria and the Actinobacteria are subject to post-translational modification by uridylylation or adenylylation respectively, whilst in some Cyanobacteria they can be modified by phosphorylation. In all these cases the protein's modification state is influenced by the cellular nitrogen status and is thought to regulate its activity. However, in many organisms there is no evidence for modification of PII proteins and indeed the ability of these proteins to respond to the cellular nitrogen status is fundamentally independent of post-translational modification. In this review we explore the role of post-translational modification in PII proteins in the light of recent studies.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 63 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 19%
Student > Bachelor 10 16%
Student > Ph. D. Student 9 14%
Student > Doctoral Student 5 8%
Researcher 5 8%
Other 12 19%
Unknown 11 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 38%
Biochemistry, Genetics and Molecular Biology 19 30%
Chemistry 4 6%
Unspecified 2 3%
Psychology 1 2%
Other 3 5%
Unknown 11 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2015.
All research outputs
#20,248,338
of 22,776,824 outputs
Outputs from Frontiers in Microbiology
#22,282
of 24,689 outputs
Outputs of similar age
#295,301
of 352,333 outputs
Outputs of similar age from Frontiers in Microbiology
#241
of 272 outputs
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