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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Ig Constant Region Effects on Variable Region Structure and Function
|
|---|---|
| Published in |
Frontiers in Microbiology, February 2016
|
| DOI | 10.3389/fmicb.2016.00022 |
| Pubmed ID | |
| Authors |
Alena Janda, Anthony Bowen, Neil S. Greenspan, Arturo Casadevall |
| Abstract |
The adaptive humoral immune response is responsible for the generation of antimicrobial proteins known as immunoglobulin molecules or antibodies. Immunoglobulins provide a defense system against pathogenic microbes and toxins by targeting them for removal and/or destruction. Historically, antibodies have been thought to be composed of distinct structural domains known as the variable and constant regions that are responsible for antigen binding and mediating effector functions such as opsonization and complement activation, respectively. These domains were thought to be structurally and functionally independent. Recent work has revealed however, that in some families of antibodies, the two regions can influence each other. We will discuss the body of work that led to these observations, as well as the mechanisms that have been proposed to explain how these two different antibody regions may interact in the function of antigen binding. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 198 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 198 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 18% |
| Student > Bachelor | 31 | 16% |
| Researcher | 30 | 15% |
| Student > Master | 21 | 11% |
| Student > Doctoral Student | 11 | 6% |
| Other | 14 | 7% |
| Unknown | 56 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 48 | 24% |
| Agricultural and Biological Sciences | 33 | 17% |
| Immunology and Microbiology | 20 | 10% |
| Medicine and Dentistry | 11 | 6% |
| Chemistry | 8 | 4% |
| Other | 18 | 9% |
| Unknown | 60 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2024.
All research outputs
#3,198,561
of 23,556,846 outputs
Outputs from Frontiers in Microbiology
#2,934
of 26,044 outputs
Outputs of similar age
#57,977
of 400,309 outputs
Outputs of similar age from Frontiers in Microbiology
#72
of 486 outputs
Altmetric has tracked 23,556,846 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 26,044 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 400,309 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 486 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.