Title |
Gut Microbiota: The Brain Peacekeeper
|
---|---|
Published in |
Frontiers in Microbiology, March 2016
|
DOI | 10.3389/fmicb.2016.00345 |
Pubmed ID | |
Authors |
Chunlong Mu, Yuxiang Yang, Weiyun Zhu |
Abstract |
Gut microbiota regulates intestinal and extraintestinal homeostasis. Accumulating evidence suggests that the gut microbiota may also regulate brain function and behavior. Results from animal models indicate that disturbances in the composition and functionality of some microbiota members are associated with neurophysiological disorders, strengthening the idea of a microbiota-gut-brain axis and the role of microbiota as a "peacekeeper" in the brain health. Here, we review recent discoveries on the role of the gut microbiota in central nervous system-related diseases. We also discuss the emerging concept of the bidirectional regulation by the circadian rhythm and gut microbiota, and the potential role of the epigenetic regulation in neuronal cell function. Microbiome studies are also highlighted as crucial in the development of targeted therapies for neurodevelopmental disorders. |
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Geographical breakdown
Country | Count | As % |
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United States | 1 | 6% |
France | 1 | 6% |
Unknown | 15 | 88% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 10 | 59% |
Scientists | 5 | 29% |
Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 2 | <1% |
India | 2 | <1% |
Russia | 2 | <1% |
United States | 2 | <1% |
United Kingdom | 2 | <1% |
Austria | 1 | <1% |
South Africa | 1 | <1% |
Greece | 1 | <1% |
France | 1 | <1% |
Other | 0 | 0% |
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Readers by professional status | Count | As % |
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Student > Bachelor | 70 | 15% |
Researcher | 67 | 14% |
Student > Master | 67 | 14% |
Student > Ph. D. Student | 54 | 11% |
Student > Postgraduate | 47 | 10% |
Other | 100 | 21% |
Unknown | 75 | 16% |
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Biochemistry, Genetics and Molecular Biology | 87 | 18% |
Medicine and Dentistry | 65 | 14% |
Neuroscience | 42 | 9% |
Immunology and Microbiology | 26 | 5% |
Other | 67 | 14% |
Unknown | 89 | 19% |