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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Second Messenger Signaling in Bacillus subtilis: Accumulation of Cyclic di-AMP Inhibits Biofilm Formation
|
|---|---|
| Published in |
Frontiers in Microbiology, May 2016
|
| DOI | 10.3389/fmicb.2016.00804 |
| Pubmed ID | |
| Authors |
Jan Gundlach, Hermann Rath, Christina Herzberg, Ulrike Mäder, Jörg Stülke |
| Abstract |
The Gram-positive model organism Bacillus subtilis produces the essential second messenger signaling nucleotide cyclic di-AMP. In B. subtilis and other bacteria, c-di-AMP has been implicated in diverse functions such as control of metabolism, cell division and cell wall synthesis, and potassium transport. To enhance our understanding of the multiple functions of this second messenger, we have studied the consequences of c-di-AMP accumulation at a global level by a transcriptome analysis. C-di-AMP accumulation affected the expression of about 700 genes, among them the two major operons required for biofilm formation. The expression of both operons was severely reduced both in the laboratory and a non-domesticated strain upon accumulation of c-di-AMP. In excellent agreement, the corresponding strain was unable to form complex colonies. In B. subtilis, the transcription factor SinR controls the expression of biofilm genes by binding to their promoter regions resulting in transcription repression. Inactivation of the sinR gene restored biofilm formation even at high intracellular c-di-AMP concentrations suggesting that the second messenger acts upstream of SinR in the signal transduction pathway. As c-di-AMP accumulation did not affect the intracellular levels of SinR, we conclude that the nucleotide affects the activity of SinR. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 13% |
| Netherlands | 1 | 13% |
| United States | 1 | 13% |
| Unknown | 5 | 63% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 5 | 63% |
| Members of the public | 3 | 38% |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 104 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 29% |
| Researcher | 16 | 15% |
| Student > Master | 16 | 15% |
| Student > Bachelor | 9 | 8% |
| Student > Doctoral Student | 5 | 5% |
| Other | 10 | 9% |
| Unknown | 19 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 36 | 34% |
| Agricultural and Biological Sciences | 26 | 25% |
| Immunology and Microbiology | 6 | 6% |
| Chemistry | 5 | 5% |
| Environmental Science | 2 | 2% |
| Other | 7 | 7% |
| Unknown | 24 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2016.
All research outputs
#6,252,837
of 22,869,263 outputs
Outputs from Frontiers in Microbiology
#6,160
of 24,888 outputs
Outputs of similar age
#99,509
of 335,837 outputs
Outputs of similar age from Frontiers in Microbiology
#191
of 563 outputs
Altmetric has tracked 22,869,263 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 24,888 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,837 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 563 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.