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Development of a Lateral Flow Immunoassay for the Rapid Diagnosis of Invasive Candidiasis

Overview of attention for article published in Frontiers in Microbiology, September 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

patent
2 patents
facebook
1 Facebook page

Citations

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23 Dimensions

Readers on

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70 Mendeley
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Title
Development of a Lateral Flow Immunoassay for the Rapid Diagnosis of Invasive Candidiasis
Published in
Frontiers in Microbiology, September 2016
DOI 10.3389/fmicb.2016.01451
Pubmed ID
Authors

Zheng-Xin He, Lan-Chun Shi, Xiang-Yang Ran, Wei Li, Xian-Ling Wang, Fu-Kun Wang

Abstract

Early and accurate diagnosis of invasive candidiasis (IC) is very important. In this study, a lateral flow immunoassay (LFIA) was developed to detect antibody against Candida albicans enolase (Eno). Colloidal gold particle labeled mouse anti human IgG (1.0 mg/L) was used as the detector reagent. Recombinant enolase (rEno, 1.0 mg/L) and goat anti IgG (1.0 mg/L) were immobilized in test and control lines, respectively, of a nitrocellulose membrane, acting as the capture reagents. The LFIA was used to detect anti Eno in 38 sera from clinically proven IC patients, as well as in 50 healthy control subjects. Compared with an indirect ELISA designed as a reference test, the specificity and sensitivity of the LFIA were 98.2 and 84.8%, respectively. Excellent agreement between the results obtained by ELISA and the LFIA (κ = 0.851) was observed in this study. In addition, the agreement between the blood culture results and LFIA test is strong (κ = 0.658). The data presented in the study indicate that the LFIA test is a suitable tool for the serological surveillance of IC in the field or in poorly equipped laboratories.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 70 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 17%
Student > Ph. D. Student 12 17%
Student > Bachelor 10 14%
Researcher 7 10%
Other 4 6%
Other 5 7%
Unknown 20 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 14%
Immunology and Microbiology 7 10%
Chemistry 7 10%
Agricultural and Biological Sciences 6 9%
Engineering 6 9%
Other 12 17%
Unknown 22 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2021.
All research outputs
#4,643,036
of 22,963,381 outputs
Outputs from Frontiers in Microbiology
#4,742
of 25,009 outputs
Outputs of similar age
#77,077
of 322,598 outputs
Outputs of similar age from Frontiers in Microbiology
#117
of 451 outputs
Altmetric has tracked 22,963,381 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 25,009 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,598 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 451 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.