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Deciphering Physiological Functions of AHL Quorum Quenching Acylases

Overview of attention for article published in Frontiers in Microbiology, June 2017
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Title
Deciphering Physiological Functions of AHL Quorum Quenching Acylases
Published in
Frontiers in Microbiology, June 2017
DOI 10.3389/fmicb.2017.01123
Pubmed ID
Authors

Putri D. Utari, Jan Vogel, Wim J. Quax

Abstract

N-Acylhomoserine lactone (AHL)-acylase (also known as amidase or amidohydrolase) is a class of enzyme that belongs to the Ntn-hydrolase superfamily. As the name implies, AHL-acylases are capable of hydrolysing AHLs, the most studied signaling molecules for quorum sensing in Gram-negative bacteria. Enzymatic degradation of AHLs can be beneficial in attenuating bacterial virulence, which can be exploited as a novel approach to fight infection of human pathogens, phytopathogens or aquaculture-related contaminations. Numerous acylases from both prokaryotic and eukaryotic sources have been characterized and tested for the interference of quorum sensing-regulated functions. The existence of AHL-acylases in a multitude of organisms from various ecological niches, raises the question of what the physiological roles of AHL-acylases actually are. In this review, we attempt to bring together recent studies to extend our understanding of the biological functions of these enzymes in nature.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 96 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 16%
Researcher 13 14%
Student > Bachelor 11 11%
Student > Doctoral Student 10 10%
Student > Master 10 10%
Other 9 9%
Unknown 28 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 20%
Biochemistry, Genetics and Molecular Biology 18 19%
Immunology and Microbiology 9 9%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Environmental Science 3 3%
Other 14 15%
Unknown 30 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2017.
All research outputs
#21,617,275
of 24,129,125 outputs
Outputs from Frontiers in Microbiology
#24,789
of 27,173 outputs
Outputs of similar age
#280,281
of 320,278 outputs
Outputs of similar age from Frontiers in Microbiology
#465
of 535 outputs
Altmetric has tracked 24,129,125 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 27,173 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 535 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.