Carlos Fernando O. R. Melo, Jeany Delafiori, Diogo N. de Oliveira, Tatiane M. Guerreiro, Cibele Z. Esteves, Estela de O. Lima, Victoria Pando-Robles, Rodrigo R. Catharino, the Zika-Unicamp Network, Guilherme P. Milanez, Gabriela M. do Nascimento, André R. R. Freitas, Rodrigo Angerami, Fábio T. Maranhão Costa, Clarice W. Arns, Mariangela R. Resende, Eliana Amaral, Renato P., Carolina C. Ribeiro-do-Valle, Helaine Milanez, Maria L. Moretti, Jose L. Proenca-Modena, Glaucia M. Pastore, Kleber Y. Fertrin, Márcia T. Garcia, Roseli Calil, João R. B. Júnior, Giuliane J. Lajos, Maria L. Costa, Marcos T. N. da Silva, Albina Altemani, Ana C. Coan, Maria F. Colella-Santos, Andrea P. B. von Zuben, Marco A. R. Vinolo, Rosemeire F. de O. de Paula, Carla C. Judice, Juliana A. Leite, Leonardo C. Caserta, Ana P. de Moraes, Ana C. S. Barnabé, Ana L. R. da Soledade, Daniel A. T. Teixeira, Évellyn R. de Morais, Felipe R. Santos
Abstract
Zika virus (ZIKV) infection has recently emerged as a major concern worldwide due to its strong association with nervous system malformation (microcephaly) of fetuses in pregnant women infected by the virus. Signs and symptoms of ZIKV infection are often mistaken with other common viral infections. Since transmission may occur through biological fluids exchange and coitus, in addition to mosquito bite, this condition is an important infectious disease. Thus, understanding the mechanism of viral infection has become an important research focus, as well as providing potential targets for assertive clinical diagnosis and quality screening for hemoderivatives. Within this context, the present work analyzed blood plasma from 79 subjects, divided as a control group and a ZIKV-infected group. Samples underwent direct-infusion mass spectrometry and statistical analysis, where eight markers related to the pathophysiological process of ZIKV infection were elected and characterized. Among these, Angiotensin (1-7) and Angiotensin I were upregulated under infection, showing an attempt to induce autophagy of the infected cells. However, this finding is concerning about hypertensive individuals under treatment with inhibitors of the Renin-Angiotensin System (RAS), which could reduce this response against the virus and exacerbate the symptoms of the infection. Moreover, one of the most abundant glycosphingolipids in the nervous tissue, Ganglioside GM2, was also elected in the present study as an infection biomarker. Considered an important pathogen receptor at membrane's outer layer, this finding represents the importance of gangliosides for ZIKV infection and its association with brain tropism. Furthermore, a series of phosphatidylinositols were also identified as biomarkers, implying a significant role of the PI3K-AKT-mTOR Pathway in this mechanism. Finally, these pathways may also be understood as potential targets to be considered in pharmacological intervention studies on ZIKV infection management.
This research output has an Altmetric Attention Score of 66. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2020.
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#554,924
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#9
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Altmetric has tracked 23,003,906 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 25,096 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 522 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.
