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Genomic Comparison among Lethal Invasive Strains of Streptococcus pyogenes Serotype M1

Overview of attention for article published in Frontiers in Microbiology, October 2017
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Title
Genomic Comparison among Lethal Invasive Strains of Streptococcus pyogenes Serotype M1
Published in
Frontiers in Microbiology, October 2017
DOI 10.3389/fmicb.2017.01993
Pubmed ID
Authors

Gabriel R. Fernandes, Aulus E. A. D. Barbosa, Renan N. Almeida, Fabíola F. dos S. Castro, Marina de C. P. da Ponte, Celio Faria-Junior, Fernanda M. P. Müller, Antônio A. B. Viana, Dario Grattapaglia, Octavio L. Franco, Sérgio A. Alencar, Simoni C. Dias

Abstract

Streptococcus pyogenes, also known as group A Streptococcus (GAS), is a human pathogen that causes diverse human diseases including streptococcal toxic shock syndrome (STSS). A GAS outbreak occurred in Brasilia, Brazil, during the second half of the year 2011, causing 26 deaths. Whole genome sequencing was performed using Illumina platform. The sequences were assembled and genes were predicted for comparative analysis with emm type 1 strains: MGAS5005 and M1 GAS. Genomics comparison revealed one of the invasive strains that differ from others isolates and from emm 1 reference genomes. Also, the new invasive strain showed differences in the content of virulence factors compared to other isolated in the same outbreak. The evolution of contemporary GAS strains is strongly associated with horizontal gene transfer. This is the first genomic study of a Streptococcal emm 1 outbreak in Brazil, and revealed the rapid bacterial evolution leading to new clones. The emergence of new invasive strains can be a consequence of the injudicious use of antibiotics in Brazil during the past decades.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Professor 6 20%
Student > Ph. D. Student 4 13%
Student > Bachelor 4 13%
Student > Master 3 10%
Researcher 2 7%
Other 2 7%
Unknown 9 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 30%
Biochemistry, Genetics and Molecular Biology 8 27%
Unspecified 1 3%
Immunology and Microbiology 1 3%
Medicine and Dentistry 1 3%
Other 0 0%
Unknown 10 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2024.
All research outputs
#15,962,021
of 25,257,066 outputs
Outputs from Frontiers in Microbiology
#14,481
of 28,993 outputs
Outputs of similar age
#190,156
of 334,828 outputs
Outputs of similar age from Frontiers in Microbiology
#328
of 537 outputs
Altmetric has tracked 25,257,066 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 28,993 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,828 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 537 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.