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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Stem Cell Transcription Factor FoxO Controls Microbiome Resilience in Hydra
|
|---|---|
| Published in |
Frontiers in Microbiology, April 2018
|
| DOI | 10.3389/fmicb.2018.00629 |
| Pubmed ID | |
| Authors |
Benedikt M. Mortzfeld, Jan Taubenheim, Sebastian Fraune, Alexander V. Klimovich, Thomas C. G. Bosch |
| Abstract |
The aging process is considered to be the result of accumulating cellular deterioration in an individual organism over time. It can be affected by the combined influence of genetic, epigenetic, and environmental factors including life-style-associated events. In the non-senescent freshwater polyp Hydra, one of the classical model systems for evolutionary developmental biology and regeneration, transcription factor FoxO modulates both stem cell proliferation and innate immunity. This provides strong support for the role of FoxO as a critical rate-of-aging regulator. However, how environmental factors interact with FoxO remains unknown. Here, we find that deficiency in FoxO signaling in Hydra leads to dysregulation of antimicrobial peptide expression and that FoxO loss-of-function polyps are impaired in selection for bacteria resembling the native microbiome and more susceptible to colonization of foreign bacteria. These findings reveal a key role of FoxO signaling in the communication between host and microbiota and embed the evolutionary conserved longevity factor FoxO into the holobiont concept. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 20% |
| France | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 58 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 19% |
| Student > Master | 11 | 19% |
| Student > Bachelor | 11 | 19% |
| Student > Ph. D. Student | 8 | 14% |
| Professor | 2 | 3% |
| Other | 5 | 9% |
| Unknown | 10 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 36% |
| Biochemistry, Genetics and Molecular Biology | 15 | 26% |
| Neuroscience | 2 | 3% |
| Environmental Science | 1 | 2% |
| Nursing and Health Professions | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 14 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2021.
All research outputs
#1,286,599
of 23,043,346 outputs
Outputs from Frontiers in Microbiology
#751
of 25,186 outputs
Outputs of similar age
#30,809
of 329,125 outputs
Outputs of similar age from Frontiers in Microbiology
#29
of 602 outputs
Altmetric has tracked 23,043,346 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 25,186 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,125 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 602 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.