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Molecular Characterization of Clostridium difficile Isolates in China From 2010 to 2015

Overview of attention for article published in Frontiers in Microbiology, April 2018
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Title
Molecular Characterization of Clostridium difficile Isolates in China From 2010 to 2015
Published in
Frontiers in Microbiology, April 2018
DOI 10.3389/fmicb.2018.00845
Pubmed ID
Authors

Xiao-shu Liu, Wen-ge Li, Wen-zhu Zhang, Yuan Wu, Jin-xing Lu

Abstract

Clostridium difficile infection (CDI) has become a worldwide public health problem causing high mortality and a large disease burden. Molecular typing and analysis is important for surveillance and infection control of CDI. However, molecular characterization of C. difficile across China is extremely rare. Here, we report on the toxin profiles, molecular subtyping with multilocus sequence typing (MLST) and PCR ribotyping, and epidemiological characteristics of 199 C. difficile isolates collected between 2010 through 2015 from 13 participating centers across China. We identified 35 STs and 27 ribotypes (RTs) among the 199 C. difficile isolates: ST35 (15.58%), ST3 (15.08%), ST37 (12.06%), and RT017 (14.07%), RT001 (12.06%), RT012 (11.56%) are the most prevalent. One isolate with ST1 and 8 isolates with ST 11 were identified. We identified a new ST in this study, denoted ST332. The toxin profile tcdA+tcdB+tcdC+tcdR+tcdE+CDT- (65.83%) was the predominant profile. Furthermore, 11 isolates with positive binary toxin genes were discovered. According to the PCR ribotyping, one isolate with RT 027, and 6 isolates with RT 078 were confirmed. The epidemiological characteristics of C. difficile in China shows geographical differences, and both the toxin profile and molecular types exhibit great diversity across the different areas.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 19%
Professor 3 14%
Other 2 10%
Student > Bachelor 2 10%
Unspecified 2 10%
Other 3 14%
Unknown 5 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 14%
Unspecified 2 10%
Immunology and Microbiology 2 10%
Medicine and Dentistry 2 10%
Nursing and Health Professions 1 5%
Other 3 14%
Unknown 8 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2018.
All research outputs
#18,612,022
of 23,055,429 outputs
Outputs from Frontiers in Microbiology
#19,615
of 25,205 outputs
Outputs of similar age
#252,368
of 325,398 outputs
Outputs of similar age from Frontiers in Microbiology
#469
of 609 outputs
Altmetric has tracked 23,055,429 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 609 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.