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A Role of a Newly Identified Isomerase From Yarrowia lipolytica in Erythritol Catabolism

Overview of attention for article published in Frontiers in Microbiology, May 2018
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Title
A Role of a Newly Identified Isomerase From Yarrowia lipolytica in Erythritol Catabolism
Published in
Frontiers in Microbiology, May 2018
DOI 10.3389/fmicb.2018.01122
Pubmed ID
Authors

Aleksandra M. Mirończuk, Anna Biegalska, Karolina Zugaj, Dorota A. Rzechonek, Adam Dobrowolski

Abstract

Erythritol is a natural sweetener produced by microorganisms as an osmoprotectant. It belongs to the group of polyols and it can be utilized by the oleaginous yeast Yarrowia lipolytica. Despite the recent identification of the transcription factor of erythritol utilization (EUF1), the metabolic pathway of erythritol catabolism remains unknown. In this study we identified a new gene, YALI0F01628g, involved in erythritol assimilation. In silico analysis showed that YALI0F01628g is a putative isomerase and it is localized in the same region as EUF1. qRT-PCR analysis of Y. lipolytica showed a significant increase in YALI0F01628g expression during growth on erythritol and after overexpression of EUF1. Moreover, the deletion strain ΔF01628 showed significantly impaired erythritol assimilation, whereas synthesis of erythritol remained unchanged. The results showed that YALI0F1628g is involved in erythritol assimilation; thus we named the gene EYI1. Moreover, we suggest the metabolic pathway of erythritol assimilation in yeast Y. lipolytica.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 32%
Student > Master 3 10%
Researcher 3 10%
Student > Bachelor 3 10%
Student > Doctoral Student 2 6%
Other 4 13%
Unknown 6 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 42%
Agricultural and Biological Sciences 5 16%
Chemistry 2 6%
Immunology and Microbiology 1 3%
Chemical Engineering 1 3%
Other 0 0%
Unknown 9 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2018.
All research outputs
#18,639,173
of 23,090,520 outputs
Outputs from Frontiers in Microbiology
#19,659
of 25,257 outputs
Outputs of similar age
#255,885
of 331,096 outputs
Outputs of similar age from Frontiers in Microbiology
#488
of 660 outputs
Altmetric has tracked 23,090,520 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 25,257 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
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We're also able to compare this research output to 660 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.