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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genome Mining of the Marine Actinomycete Streptomyces sp. DUT11 and Discovery of Tunicamycins as Anti-complement Agents
|
|---|---|
| Published in |
Frontiers in Microbiology, June 2018
|
| DOI | 10.3389/fmicb.2018.01318 |
| Pubmed ID | |
| Authors |
Xiao-Na Xu, Liang-Yu Chen, Chao Chen, Ya-Jie Tang, Feng-Wu Bai, Chun Su, Xin-Qing Zhao |
| Abstract |
Marine actinobacteria are potential producers of various secondary metabolites with diverse bioactivities. Among various bioactive compounds, anti-complement agents have received great interest for drug discovery to treat numerous diseases caused by inappropriate activation of the human complement system. However, marine streptomycetes producing anti-complement agents are still poorly explored. In this study, a marine-derived strain Streptomyces sp. DUT11 showing superior anti-complement activity was focused, and its genome sequence was analyzed. Gene clusters showing high similarities to that of tunicamycin and nonactin were identified, and their corresponding metabolites were also detected. Subsequently, tunicamycin I, V, and VII were isolated from Streptomyces sp. DUT11. Anti-complement assay showed that tunicamycin I, V, VII inhibited complement activation through the classic pathway, whereas no anti-complement activity of nonactin was detected. This is the first time that tunicamycins are reported to have such activity. In addition, genome analysis indicates that Streptomyces sp. DUT11 has the potential to produce novel lassopeptides and lantibiotics. These results suggest that marine Streptomyces are rich sources of anti-complement agents for drug discovery. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 2 | 67% |
| United Kingdom | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 33% |
| Student > Bachelor | 6 | 12% |
| Student > Master | 5 | 10% |
| Student > Doctoral Student | 3 | 6% |
| Lecturer | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 15 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 15% |
| Agricultural and Biological Sciences | 8 | 15% |
| Chemistry | 5 | 10% |
| Immunology and Microbiology | 4 | 8% |
| Environmental Science | 3 | 6% |
| Other | 7 | 13% |
| Unknown | 17 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2018.
All research outputs
#13,545,254
of 23,094,276 outputs
Outputs from Frontiers in Microbiology
#10,505
of 25,264 outputs
Outputs of similar age
#167,363
of 328,092 outputs
Outputs of similar age from Frontiers in Microbiology
#336
of 716 outputs
Altmetric has tracked 23,094,276 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 25,264 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,092 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 716 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.