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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CRISPR/Cas9-Based Editing of Streptomyces for Discovery, Characterization, and Production of Natural Products
|
|---|---|
| Published in |
Frontiers in Microbiology, July 2018
|
| DOI | 10.3389/fmicb.2018.01660 |
| Pubmed ID | |
| Authors |
Weixin Tao, Anna Yang, Zixin Deng, Yuhui Sun |
| Abstract |
Microbial natural products (NPs) especially of the Streptomyces genus have been regarded as an unparalleled resource for pharmaceutical drugs discovery. Moreover, recent progress in sequencing technologies and computational resources further reinforces to identify numerous NP biosynthetic gene clusters (BGCs) from the genomes of Streptomyces. However, the majority of these BGCs are silent or poorly expressed in native strains and remain to be activated and investigated, which relies heavily on efficient genome editing approaches. Accordingly, numerous strategies are developed, especially, the most recently developed, namely, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated (Cas) system reveals remarkable higher accuracy and efficiency for genome editing in various model organisms including the Streptomyces. In this mini review, we highlight the application of CRISPR/Cas9-based approaches in Streptomyces, focus on the editing of BGCs either in vivo or in vitro, as well as target cloning of large-sized BGCs and heterologous expression in a genetically manipulatable host, for discovery, characterization, reengineering, and production of potential pharmaceutical drugs. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 10% |
| United States | 1 | 5% |
| Netherlands | 1 | 5% |
| Sweden | 1 | 5% |
| Germany | 1 | 5% |
| Mexico | 1 | 5% |
| Canada | 1 | 5% |
| Unknown | 12 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 10 | 50% |
| Members of the public | 10 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 154 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 154 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 18% |
| Researcher | 19 | 12% |
| Student > Bachelor | 19 | 12% |
| Student > Master | 15 | 10% |
| Student > Doctoral Student | 7 | 5% |
| Other | 15 | 10% |
| Unknown | 51 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 56 | 36% |
| Agricultural and Biological Sciences | 19 | 12% |
| Chemistry | 6 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Immunology and Microbiology | 4 | 3% |
| Other | 13 | 8% |
| Unknown | 51 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2019.
All research outputs
#3,266,844
of 25,363,868 outputs
Outputs from Frontiers in Microbiology
#2,876
of 29,274 outputs
Outputs of similar age
#62,100
of 340,505 outputs
Outputs of similar age from Frontiers in Microbiology
#119
of 742 outputs
Altmetric has tracked 25,363,868 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 29,274 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,505 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 742 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.