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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Development and Characterization of a Novel Live Attenuated Vaccine Against Enteric Septicemia of Catfish
|
|---|---|
| Published in |
Frontiers in Microbiology, August 2018
|
| DOI | 10.3389/fmicb.2018.01819 |
| Pubmed ID | |
| Authors |
Hossam Abdelhamed, Mark L. Lawrence, Attila Karsi |
| Abstract |
Edwardsiella ictaluri is a Gram-negative intracellular pathogen causing enteric septicemia of channel catfish (ESC). Type six secretion system (T6SS) is a sophisticated nanomachine that delivers effector proteins into eukaryotic host cells as well as other bacteria. In the current work, we in-frame deleted the E. ictalurievpB gene located in the T6SS operon by allelic exchange. The safety and efficacy of EiΔevpB as well as Aquavac-ESC, a commercial vaccine manufactured by Intervet/Merck Animal Health, were evaluated in channel catfish (Ictalurus punctatus) fingerlings and fry by immersion exposure. Our results showed that the EiΔevpB strain was avirulent and fully protective in catfish fingerlings. The EiΔevpB strain was also safe in catfish fry, and immersion vaccination with EiΔevpB at doses 106 and 107 CFU/ml in water resulted in 34.24 and 80.34% survival after wild-type immersion challenge compared to sham-vaccinated fry (1.79% survival). Catfish fry vaccinated with EiΔevpB at doses 106, 107, and 108 CFU/ml in water exhibited dose-dependent protection. When compared with Aquavac-ESC, EiΔevpB provided significantly higher protection in catfish fingerlings and fry (p < 0.05). Results indicate that the EiΔevpB strain is safe and can be used to protect catfish fingerlings and fry against E. ictaluri. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 31 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 16% |
| Researcher | 4 | 13% |
| Student > Bachelor | 2 | 6% |
| Student > Master | 2 | 6% |
| Professor | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 14 | 45% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 19% |
| Biochemistry, Genetics and Molecular Biology | 3 | 10% |
| Veterinary Science and Veterinary Medicine | 2 | 6% |
| Immunology and Microbiology | 2 | 6% |
| Philosophy | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 15 | 48% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2018.
All research outputs
#20,663,600
of 25,385,509 outputs
Outputs from Frontiers in Microbiology
#22,990
of 29,299 outputs
Outputs of similar age
#264,693
of 340,782 outputs
Outputs of similar age from Frontiers in Microbiology
#583
of 749 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 29,299 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,782 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 749 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.