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X Demographics
Attention Score in Context
| Title |
Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral Infection
|
|---|---|
| Published in |
Frontiers in Microbiology, February 2022
|
| DOI | 10.3389/fmicb.2022.798660 |
| Pubmed ID | |
| Authors |
Shu-Ting Song, Meng-Li Wu, Hai-Jiao Zhang, Xiao Su, Jian-Hua Wang |
| Abstract |
Mast cells (MCs) are strategically located at the host-environment interface and their non-allergic roles in the immune-surveillance of pathogens have recently gained more attention. However, MC-caused detrimental regulation of immune inflammations can promote viral invasion. Currently, the role of MCs in retroviral infection remains elusive. We have recently proved that human gut MCs could capture and transfer HIV-1 to CD4+ T cells for promoting viral spread; MC-released histamine augments HIV-1-induced functional polarization of dendritic cells to cause immunosuppression via stimulating the differentiation of regulatory T cells. In this study, we used a murine model of MuLV/Friend virus infection to address MC role in acute retroviral infection in vivo. The acute infection of MuLV/Friend virus could be established in C57BL/6 wild type mice, but viral acquisition showed low efficiency in C57BL/6-Kit W - sh/W - sh (Sash) mice which lack MCs. In mechanism, we found that MuLV/Friend virus triggered MC activation for degranulation; MC degranulation subsequently activated the granulocyte-like myeloid derived suppressive cells (G-MDSCs) to inhibit CD8+ T cells- and NK cells-mediated antiviral immune responses. The reconstruction of MCs in Sash mice promoted acute retroviral infection by regulating G-MDSCs functions and antiviral immune responses. Importantly, the administration of MC stabilizers to block cell degranulation elevated antiviral immune response and consequently suppressed retrovirus infection. This study uncovers a specific role of MCs in acute retroviral infection and elucidates the underlying immune-mechanisms. Targeting MCs may provide a novel approach for controlling acute infection by retroviruses. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 8% |
| Austria | 2 | 5% |
| Japan | 2 | 5% |
| Unknown | 31 | 82% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 34 | 89% |
| Scientists | 3 | 8% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2023.
All research outputs
#1,661,115
of 26,522,772 outputs
Outputs from Frontiers in Microbiology
#1,023
of 30,403 outputs
Outputs of similar age
#41,270
of 536,998 outputs
Outputs of similar age from Frontiers in Microbiology
#33
of 1,141 outputs
Altmetric has tracked 26,522,772 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 30,403 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 536,998 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 1,141 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.