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Mediation of organismal aging and somatic proteostasis by the germline

Overview of attention for article published in Frontiers in Molecular Biosciences, January 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

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1 blog
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5 X users

Citations

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23 Dimensions

Readers on

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64 Mendeley
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Title
Mediation of organismal aging and somatic proteostasis by the germline
Published in
Frontiers in Molecular Biosciences, January 2015
DOI 10.3389/fmolb.2015.00003
Pubmed ID
Authors

Amirabbas Khodakarami, Isabel Saez, Johanna Mels, David Vilchez

Abstract

Experimental interventions that reduce reproduction cause an extension in lifespan. In invertebrates, such as Caenorhabditis elegans, the aging of the soma is regulated by signals from the germline. Indeed, ablation of germ cells significantly extends lifespan. Notably, germline-deficient animals exhibit heightened resistance to proteotoxic stress. This phenotype correlates with increased potential of intracellular clearance mechanisms such as the proteasome and autophagy in somatic tissues. Here we review the molecular mechanisms by which signals from the germline regulate lifespan in C. elegans with special emphasis on clearance mechanisms.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Turkey 1 2%
Unknown 61 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 20%
Student > Ph. D. Student 12 19%
Student > Bachelor 11 17%
Student > Master 6 9%
Other 3 5%
Other 8 13%
Unknown 11 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 38%
Biochemistry, Genetics and Molecular Biology 14 22%
Medicine and Dentistry 5 8%
Neuroscience 3 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 5 8%
Unknown 12 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2015.
All research outputs
#2,413,440
of 22,778,347 outputs
Outputs from Frontiers in Molecular Biosciences
#142
of 3,747 outputs
Outputs of similar age
#36,656
of 351,530 outputs
Outputs of similar age from Frontiers in Molecular Biosciences
#1
of 7 outputs
Altmetric has tracked 22,778,347 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,747 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 351,530 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them