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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The nucleotide exchange factors of Hsp70 molecular chaperones
|
|---|---|
| Published in |
Frontiers in Molecular Biosciences, April 2015
|
| DOI | 10.3389/fmolb.2015.00010 |
| Pubmed ID | |
| Authors |
Andreas Bracher, Jacob Verghese |
| Abstract |
Molecular chaperones of the Hsp70 family form an important hub in the cellular protein folding networks in bacteria and eukaryotes, connecting translation with the downstream machineries of protein folding and degradation. The Hsp70 folding cycle is driven by two types of cochaperones: J-domain proteins stimulate ATP hydrolysis by Hsp70, while nucleotide exchange factors (NEFs) promote replacement of Hsp70-bound ADP with ATP. Bacteria and organelles of bacterial origin have only one known NEF type for Hsp70, GrpE. In contrast, a large diversity of Hsp70 NEFs has been discovered in the eukaryotic cell. These NEFs belong to the Hsp110/Grp170, HspBP1/Sil1, and BAG domain protein families. In this short review we compare the structures and molecular mechanisms of nucleotide exchange factors for Hsp70 and discuss how these cochaperones contribute to protein folding and quality control in the cell. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 236 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Kazakhstan | 1 | <1% |
| Norway | 1 | <1% |
| Unknown | 234 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 47 | 20% |
| Student > Bachelor | 28 | 12% |
| Student > Master | 27 | 11% |
| Researcher | 24 | 10% |
| Student > Doctoral Student | 18 | 8% |
| Other | 25 | 11% |
| Unknown | 67 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 97 | 41% |
| Agricultural and Biological Sciences | 36 | 15% |
| Medicine and Dentistry | 9 | 4% |
| Chemistry | 6 | 3% |
| Physics and Astronomy | 5 | 2% |
| Other | 13 | 6% |
| Unknown | 70 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2024.
All research outputs
#7,724,098
of 26,352,576 outputs
Outputs from Frontiers in Molecular Biosciences
#775
of 4,803 outputs
Outputs of similar age
#83,845
of 280,837 outputs
Outputs of similar age from Frontiers in Molecular Biosciences
#7
of 20 outputs
Altmetric has tracked 26,352,576 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 4,803 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,837 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.