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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Lessons from two prevalent amyloidoses—what amylin and Aβ have in common
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, January 2013
|
| DOI | 10.3389/fnagi.2013.00038 |
| Pubmed ID | |
| Authors |
Jürgen Götz, Yun-An Lim, Anne Eckert |
| Abstract |
The amyloidogenic peptide Aβ plays a key role in Alzheimer's disease (AD) forming insoluble aggregates in the brain. The peptide shares its amyloidogenic properties with amylin that forms aggregates in the pancreas of patients with Type 2 Diabetes mellitus (T2DM). While epidemiological studies establish a link between these two diseases, it is becoming increasingly clear that they also share biochemical features suggesting common pathogenic mechanisms. We discuss commonalities as to how Aβ and amylin deregulate the cellular proteome, how they impair mitochondrial functions, to which receptors they bind, aspects of their clearance and how therapeutic strategies exploit the commonalities between Aβ and amylin. We conclude that research into these two molecules is mutually beneficial for the treatment of AD and T2DM. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 33% |
| Spain | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 57 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 31% |
| Student > Ph. D. Student | 8 | 14% |
| Student > Master | 8 | 14% |
| Student > Bachelor | 6 | 10% |
| Student > Doctoral Student | 3 | 5% |
| Other | 8 | 14% |
| Unknown | 8 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 17% |
| Biochemistry, Genetics and Molecular Biology | 9 | 15% |
| Agricultural and Biological Sciences | 8 | 14% |
| Neuroscience | 8 | 14% |
| Chemistry | 4 | 7% |
| Other | 12 | 20% |
| Unknown | 8 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2022.
All research outputs
#15,063,168
of 23,179,757 outputs
Outputs from Frontiers in Aging Neuroscience
#3,433
of 4,894 outputs
Outputs of similar age
#177,591
of 282,986 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#45
of 77 outputs
Altmetric has tracked 23,179,757 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,894 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.2. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,986 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.