The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cortisol, cytokines, and hippocampal volume interactions in the elderly
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, July 2014
|
| DOI | 10.3389/fnagi.2014.00153 |
| Pubmed ID | |
| Authors |
Keith D. Sudheimer, Ruth O'Hara, David Spiegel, Bevin Powers, Helena C. Kraemer, Eric Neri, Michael Weiner, Antonio Hardan, Joachim Hallmayer, Firdaus S. Dhabhar |
| Abstract |
Separate bodies of literature report that elevated pro-inflammatory cytokines and cortisol negatively affect hippocampal structure and cognitive functioning, particularly in older adults. Although interactions between cytokines and cortisol occur through a variety of known mechanisms, few studies consider how their interactions affect brain structure. In this preliminary study, we assess the impact of interactions between circulating levels of IL-1Beta, IL-6, IL-8, IL-10, IL-12, TNF-alpha, and waking cortisol on hippocampal volume. Twenty-eight community-dwelling older adults underwent blood draws for quantification of circulating cytokines and saliva collections to quantify the cortisol awakening response. Hippocampal volume measurements were made using structural magnetic resonance imaging. Elevated levels of waking cortisol in conjunction with higher concentrations of IL-6 and TNF-alpha were associated with smaller hippocampal volumes. In addition, independent of cortisol, higher levels of IL-1beta and TNF-alpha were also associated with smaller hippocampal volumes. These data provide preliminary evidence that higher cortisol, in conjunction with higher IL-6 and TNF-alpha, are associated with smaller hippocampal volume in older adults. We suggest that the dynamic balance between the hypothalamic-pituitary adrenal axis and inflammation processes may explain hippocampal volume reductions in older adults better than either set of measures do in isolation. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 152 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Portugal | 1 | <1% |
| Bulgaria | 1 | <1% |
| Germany | 1 | <1% |
| Brazil | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 145 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 24% |
| Student > Master | 17 | 11% |
| Researcher | 16 | 11% |
| Student > Bachelor | 14 | 9% |
| Student > Doctoral Student | 11 | 7% |
| Other | 23 | 15% |
| Unknown | 34 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 29 | 19% |
| Medicine and Dentistry | 23 | 15% |
| Neuroscience | 17 | 11% |
| Agricultural and Biological Sciences | 13 | 9% |
| Biochemistry, Genetics and Molecular Biology | 8 | 5% |
| Other | 21 | 14% |
| Unknown | 41 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2024.
All research outputs
#15,028,095
of 25,162,879 outputs
Outputs from Frontiers in Aging Neuroscience
#3,474
of 5,438 outputs
Outputs of similar age
#117,202
of 233,954 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#39
of 67 outputs
Altmetric has tracked 25,162,879 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,954 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.