Title |
Targeting Cholesterol Homeostasis to Fight Hearing Loss: A New Perspective
|
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Published in |
Frontiers in Aging Neuroscience, January 2015
|
DOI | 10.3389/fnagi.2015.00003 |
Pubmed ID | |
Authors |
Brigitte Malgrange, Isabel Varela-Nieto, Philippe de Medina, Michael R. Paillasse |
Abstract |
Sensorineural hearing loss (SNHL) is a major pathology of the inner ear that affects nearly 600 million people worldwide. Despite intensive researches, this major health problem remains without satisfactory solutions. The pathophysiological mechanisms involved in SNHL include oxidative stress, excitotoxicity, inflammation, and ischemia, resulting in synaptic loss, axonal degeneration, and apoptosis of spiral ganglion neurons. The mechanisms associated with SNHL are shared with other neurodegenerative disorders. Cholesterol homeostasis is central to numerous pathologies including neurodegenerative diseases and cholesterol regulates major processes involved in neurons survival and function. The role of cholesterol homeostasis in the physiopathology of inner ear is largely unexplored. In this review, we discuss the findings concerning cholesterol homeostasis in neurodegenerative diseases and whether it should be translated into potential therapeutic strategies for the treatment of SNHL. |
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Unknown | 3 | 100% |
Demographic breakdown
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 22% |
Other | 4 | 11% |
Student > Master | 4 | 11% |
Professor > Associate Professor | 3 | 8% |
Student > Doctoral Student | 2 | 6% |
Other | 7 | 19% |
Unknown | 8 | 22% |
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Biochemistry, Genetics and Molecular Biology | 7 | 19% |
Neuroscience | 5 | 14% |
Chemistry | 2 | 6% |
Agricultural and Biological Sciences | 2 | 6% |
Other | 3 | 8% |
Unknown | 9 | 25% |