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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Interaction of basal forebrain cholinergic neurons with the glucocorticoid system in stress regulation and cognitive impairment
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, April 2015
|
| DOI | 10.3389/fnagi.2015.00043 |
| Pubmed ID | |
| Authors |
Saswati Paul, Won Kyung Jeon, Jennifer L. Bizon, Jung-Soo Han |
| Abstract |
A substantial number of studies on basal forebrain (BF) cholinergic neurons (BFCN) have provided compelling evidence for their role in the etiology of stress, cognitive aging, Alzheimer's disease (AD), and other neurodegenerative diseases. BFCN project to a broad range of cortical sites and limbic structures, including the hippocampus, and are involved in stress and cognition. In particular, the hippocampus, the primary target tissue of the glucocorticoid stress hormones, is associated with cognitive function in tandem with hypothalamic-pituitary-adrenal (HPA) axis modulation. The present review summarizes glucocorticoid and HPA axis research to date in an effort to establish the manner in which stress affects the release of acetylcholine (ACh), glucocorticoids, and their receptor in the context of cognitive processes. We attempt to provide the molecular interactive link between the glucocorticoids and cholinergic system that contributes to BFCN degeneration in stress-induced acceleration of cognitive decline in aging and AD. We also discuss the importance of animal models in facilitating such studies for pharmacological use, to which could help decipher disease states and propose leads for pharmacological intervention. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 211 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Spain | 1 | <1% |
| Unknown | 208 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 47 | 22% |
| Student > Bachelor | 28 | 13% |
| Researcher | 27 | 13% |
| Student > Master | 21 | 10% |
| Student > Doctoral Student | 15 | 7% |
| Other | 25 | 12% |
| Unknown | 48 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 55 | 26% |
| Agricultural and Biological Sciences | 34 | 16% |
| Biochemistry, Genetics and Molecular Biology | 22 | 10% |
| Medicine and Dentistry | 12 | 6% |
| Psychology | 10 | 5% |
| Other | 17 | 8% |
| Unknown | 61 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2022.
All research outputs
#20,452,106
of 25,134,448 outputs
Outputs from Frontiers in Aging Neuroscience
#4,653
of 5,432 outputs
Outputs of similar age
#200,375
of 269,682 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#40
of 43 outputs
Altmetric has tracked 25,134,448 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,432 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.4. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,682 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.