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Potential of adipose-derived stem cells in muscular regenerative therapies

Overview of attention for article published in Frontiers in Aging Neuroscience, July 2015
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Title
Potential of adipose-derived stem cells in muscular regenerative therapies
Published in
Frontiers in Aging Neuroscience, July 2015
DOI 10.3389/fnagi.2015.00123
Pubmed ID
Authors

Sonia-V Forcales

Abstract

Regenerative capacity of skeletal muscles resides in satellite cells, a self-renewing population of muscle cells. Several studies are investigating epigenetic mechanisms that control myogenic proliferation and differentiation to find new approaches that could boost regeneration of endogenous myogenic progenitor populations. In recent years, a lot of effort has been applied to purify, expand and manipulate adult stem cells from muscle tissue. However, this population of endogenous myogenic progenitors in adults is limited and their access is difficult and invasive. Therefore, other sources of stem cells with potential to regenerate muscles need to be examined. An excellent candidate could be a population of adult stromal cells within fat characterized by mesenchymal properties, which have been termed adipose-derived stem cells (ASCs). These progenitor adult stem cells have been successfully differentiated in vitro to osteogenic, chondrogenic, neurogenic and myogenic lineages. Autologous ASCs are multipotent and can be harvested with low morbidity; thus, they hold promise for a range of therapeutic applications. This review will summarize the use of ASCs in muscle regenerative approaches.

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X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Brazil 1 <1%
Unknown 107 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 17%
Student > Master 17 16%
Researcher 14 13%
Student > Bachelor 9 8%
Student > Postgraduate 5 5%
Other 16 15%
Unknown 30 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 24 22%
Medicine and Dentistry 19 17%
Agricultural and Biological Sciences 15 14%
Engineering 7 6%
Materials Science 3 3%
Other 8 7%
Unknown 33 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2015.
All research outputs
#17,765,638
of 22,816,807 outputs
Outputs from Frontiers in Aging Neuroscience
#3,794
of 4,773 outputs
Outputs of similar age
#176,648
of 262,601 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#47
of 60 outputs
Altmetric has tracked 22,816,807 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,773 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,601 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.