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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Elevated body mass index and maintenance of cognitive function in late life: exploring underlying neural mechanisms
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, August 2015
|
| DOI | 10.3389/fnagi.2015.00155 |
| Pubmed ID | |
| Authors |
Chun Liang Hsu, Michelle W. Voss, John R. Best, Todd C. Handy, Kenneth Madden, Niousha Bolandzadeh, Teresa Liu-Ambrose |
| Abstract |
Obesity is associated with vascular risk factors that in turn, may increase dementia risk. However, higher body mass index (BMI) in late life may be neuroprotective. The possible neural mechanisms underlying the benefit of higher BMI on cognition in older adults are largely unknown. Thus, we used functional connectivity magnetic resonance imaging (fcMRI) to examine: (1) the relationship between BMI and functional brain connectivity; and (2) the mediating role of functional brain connectivity in the association between baseline BMI and change in cognitive function over a 12-month period. We conducted a 12-month, prospective study among 66 community-dwelling older adults, aged 70 to 80 years, who were categorized as: normal weight (BMI from 18.50 to 24.99); overweight (BMI from 25.00 to 29.99); and obese (BMI ≥ 30.00). At baseline, participants performed a finger-tapping task during fMRI scanning. Relevant neural networks were initially identified through independent component analysis (ICA) and subsequently examined through seed-based functional connectivity analysis. At baseline and 12-months, we measured three executive cognitive processes: (1) response inhibition; (2) set shifting; and (3) working memory. Obese individuals showed lower task-related functional connectivity during finger tapping in the default mode network (DMN) compared with their healthy weight counterparts (p < 0.01). Lower task-related functional connectivity in the DMN at baseline was independently associated with better working memory performance at 12-months (p = 0.02). Finally, DMN functional connectivity during finger tapping significantly mediated the relationship between baseline BMI and working memory at 12-months (indirect effect: -0.155, 95% confidence interval [-0.313, -0.053]). These findings suggest that functional connectivity of the DMN may be an underlying mechanism by which higher BMI confers protective effects to cognition in late life. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 141 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 140 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 16% |
| Researcher | 23 | 16% |
| Student > Master | 23 | 16% |
| Student > Bachelor | 12 | 9% |
| Student > Doctoral Student | 7 | 5% |
| Other | 21 | 15% |
| Unknown | 32 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 36 | 26% |
| Medicine and Dentistry | 17 | 12% |
| Neuroscience | 15 | 11% |
| Nursing and Health Professions | 8 | 6% |
| Social Sciences | 6 | 4% |
| Other | 20 | 14% |
| Unknown | 39 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2015.
All research outputs
#20,712,517
of 23,312,088 outputs
Outputs from Frontiers in Aging Neuroscience
#4,413
of 4,938 outputs
Outputs of similar age
#224,448
of 267,222 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#52
of 59 outputs
Altmetric has tracked 23,312,088 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,938 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,222 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.