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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Probing astrocyte metabolism in vivo: proton magnetic resonance spectroscopy in the injured and aging brain
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, October 2015
|
| DOI | 10.3389/fnagi.2015.00202 |
| Pubmed ID | |
| Authors |
Janna L. Harris, In-Young Choi, William M. Brooks |
| Abstract |
Following a brain injury, the mobilization of reactive astrocytes is part of a complex neuroinflammatory response that may have both harmful and beneficial effects. There is also evidence that astrocytes progressively accumulate in the normal aging brain, increasing in both number and size. These astrocyte changes in normal brain aging may, in the event of an injury, contribute to the exacerbated injury response and poorer outcomes observed in older traumatic brain injury (TBI) survivors. Here we present our view that proton magnetic resonance spectroscopy ((1)H-MRS), a neuroimaging approach that probes brain metabolism within a defined region of interest, is a promising technique that may provide insight into astrocyte metabolic changes in the injured and aging brain in vivo. Although (1)H-MRS does not specifically differentiate between cell types, it quantifies certain metabolites that are highly enriched in astrocytes (e.g., Myo-inositol, mlns), or that are involved in metabolic shuttling between astrocytes and neurons (e.g., glutamate and glutamine). Here we focus on metabolites detectable by (1)H-MRS that may serve as markers of astrocyte metabolic status. We review the physiological roles of these metabolites, discuss recent (1)H-MRS findings in the injured and aging brain, and describe how an astrocyte metabolite profile approach might be useful in clinical medicine and clinical trials. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 87 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 24% |
| Researcher | 16 | 18% |
| Student > Master | 10 | 11% |
| Professor > Associate Professor | 6 | 7% |
| Student > Bachelor | 6 | 7% |
| Other | 12 | 13% |
| Unknown | 18 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 19 | 21% |
| Biochemistry, Genetics and Molecular Biology | 12 | 13% |
| Medicine and Dentistry | 9 | 10% |
| Agricultural and Biological Sciences | 5 | 6% |
| Chemistry | 4 | 4% |
| Other | 13 | 15% |
| Unknown | 27 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2015.
All research outputs
#15,298,422
of 22,831,537 outputs
Outputs from Frontiers in Aging Neuroscience
#3,561
of 4,780 outputs
Outputs of similar age
#166,079
of 284,642 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#37
of 51 outputs
Altmetric has tracked 22,831,537 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,780 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,642 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.