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Habituation in the Tail Withdrawal Reflex Circuit is Impaired During Aging in Aplysia californica

Overview of attention for article published in Frontiers in Aging Neuroscience, February 2016
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Title
Habituation in the Tail Withdrawal Reflex Circuit is Impaired During Aging in Aplysia californica
Published in
Frontiers in Aging Neuroscience, February 2016
DOI 10.3389/fnagi.2016.00024
Pubmed ID
Authors

Andrew T. Kempsell, Lynne A. Fieber

Abstract

The relevance of putative contributors to age-related memory loss are poorly understood. The tail withdrawal circuit of the sea hare, a straightforward neural model, was used to investigate the aging characteristics of rudimentary learning. The simplicity of this neuronal circuit permits attribution of declines in the function of specific neurons to aging declines. Memory was impaired in advanced age animals compared to their performance at the peak of sexual maturity, with habituation training failing to attenuate the tail withdrawal response or to reduce tail motoneuron excitability, as occurred in peak maturity siblings. Baseline motoneuron excitability of aged animals was significantly lower, perhaps contributing to a smaller scope for attenuation. Conduction velocity in afferent fibers to tail sensory neurons (SN) decreased during aging. The findings suggest that age-related changes in tail sensory and motor neurons result in deterioration of a simple form of learning in Aplysia.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 22%
Student > Ph. D. Student 3 17%
Professor > Associate Professor 2 11%
Student > Doctoral Student 1 6%
Librarian 1 6%
Other 3 17%
Unknown 4 22%
Readers by discipline Count As %
Environmental Science 2 11%
Immunology and Microbiology 2 11%
Psychology 2 11%
Neuroscience 2 11%
Medicine and Dentistry 2 11%
Other 3 17%
Unknown 5 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2016.
All research outputs
#20,306,690
of 22,846,662 outputs
Outputs from Frontiers in Aging Neuroscience
#4,303
of 4,792 outputs
Outputs of similar age
#337,075
of 400,467 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#66
of 77 outputs
Altmetric has tracked 22,846,662 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,792 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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