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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Association between APOE Genotype and Change in Physical Function in a Population-Based Swedish Cohort of Older Individuals Followed Over Four Years
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, October 2016
|
| DOI | 10.3389/fnagi.2016.00225 |
| Pubmed ID | |
| Authors |
Ingmar Skoog, Helena Hörder, Kerstin Frändin, Lena Johansson, Svante Östling, Kaj Blennow, Henrik Zetterberg, Anna Zettergren |
| Abstract |
The association between decline in physical function and age-related conditions, such as reduced cognitive performance and vascular disease, may be explained by genetic influence on shared biological pathways of importance for aging. The apolipoprotein E (APOE) gene is well-known for its association with Alzheimer's disease, but has also been related to other disorders of importance for aging. The aim of this study was to investigate possible associations between APOE allele status and physical function in a population-based longitudinal study of older individuals. In 2005, at the age of 75, 622 individuals underwent neuropsychiatric and physical examinations, including tests of physical function, and APOE-genotyping. Follow-up examinations were performed at age 79. A significantly larger decline in grip strength (p = 0.015) between age 75 and 79 was found when comparing APOE 𝜀4 allele carriers with non-carriers [10.3 (±10.8) kg versus 7.8 (±10.1) kg]. No association was seen with decline in gait speed, chair-stand, or balance. The association with grip strength remained after correction for cognitive and educational level, depression, cardiovascular disease, stroke, and BMI. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 58 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 12 | 21% |
| Student > Master | 8 | 14% |
| Student > Ph. D. Student | 7 | 12% |
| Researcher | 5 | 9% |
| Student > Doctoral Student | 4 | 7% |
| Other | 8 | 14% |
| Unknown | 14 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 9 | 16% |
| Medicine and Dentistry | 7 | 12% |
| Nursing and Health Professions | 7 | 12% |
| Unspecified | 3 | 5% |
| Biochemistry, Genetics and Molecular Biology | 3 | 5% |
| Other | 11 | 19% |
| Unknown | 18 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2016.
All research outputs
#15,385,802
of 22,890,496 outputs
Outputs from Frontiers in Aging Neuroscience
#3,615
of 4,820 outputs
Outputs of similar age
#201,635
of 319,862 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#48
of 69 outputs
Altmetric has tracked 22,890,496 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,820 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.0. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,862 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.