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No Association between Elevated Total Homocysteine Levels and Functional Outcome in Elderly Patients with Acute Cerebral Infarction

Overview of attention for article published in Frontiers in Aging Neuroscience, March 2017
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Title
No Association between Elevated Total Homocysteine Levels and Functional Outcome in Elderly Patients with Acute Cerebral Infarction
Published in
Frontiers in Aging Neuroscience, March 2017
DOI 10.3389/fnagi.2017.00070
Pubmed ID
Authors

Wanjun Wang, Chunlin Gao, Changshen Yu, Shoufeng Liu, Dongzhe Hou, Yajing Wang, Chen Wang, Lidong Mo, Jialing Wu

Abstract

Background: An elevated plasma total homocysteine (tHcy) level is an independent risk factor for vascular events. The aim of the present study was to investigate the association between tHcy levels in the acute phase of cerebral infarction and functional outcome among elderly patients. Methods: Between October 2009 and December 2012, we recruited 594 elderly patients (age > 75) with first-onset acute cerebral infarction who were consecutively admitted to the Department of Neurology of Tianjin Huanhu Hospital, China. Levels of tHcy and other biochemical values were measured within 24 h after admission. tHcy values were classified according to quartiles (<9.94; 9.94 to <12.7; 12.7 to <16.8; and ≥16.8 μmol/L). We examined the relationship between tHcy levels at admission and modified Rankin Scale scores (mRS) using univariate and multivariate analyses. Patients were followed up at 3 months and 1 year after stroke. Results: Within 3 months after stroke, 64 patients died, 37 had recurrent ischemic stroke, and 22 were lost to follow-up; thus, 471 patients were reviewed and analyzed. By the time of the 1-year follow-up, an additional 48 patients had died, 44 had recurrent ischemic stroke, and 40 had been lost to follow-up; the remaining 339 patients were thus reviewed and analyzed. Elevated tHcy levels were not associated with functional outcome among elderly patients with acute cerebral infarction (p > 0.05). Only the National Institutes of Health Stroke Scale score was associated with a poor outcome after adjusting for confounders at 3 months and 1 year (adjusted odds ratio, 1.38; 95% CI, 1.28-1.49; p < 0.01; adjusted odds ratio, 1.34; 95% CI, 1.25-1.44; p < 0.01, respectively). Conclusion: Among elderly patients with acute cerebral infarction, elevated tHcy at admission was not a predictive factor of outcome at 3 months and 1 year after stroke onset.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 15%
Lecturer 1 8%
Student > Bachelor 1 8%
Student > Ph. D. Student 1 8%
Student > Master 1 8%
Other 2 15%
Unknown 5 38%
Readers by discipline Count As %
Medicine and Dentistry 4 31%
Biochemistry, Genetics and Molecular Biology 1 8%
Economics, Econometrics and Finance 1 8%
Psychology 1 8%
Unknown 6 46%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2017.
All research outputs
#20,411,380
of 22,961,203 outputs
Outputs from Frontiers in Aging Neuroscience
#4,327
of 4,832 outputs
Outputs of similar age
#269,614
of 309,329 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#102
of 110 outputs
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So far Altmetric has tracked 4,832 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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