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An Examination of Brain Abnormalities and Mobility in Individuals with Mild Cognitive Impairment and Alzheimer's Disease

Overview of attention for article published in Frontiers in Aging Neuroscience, April 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

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1 news outlet
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5 X users

Citations

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4 Dimensions

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57 Mendeley
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Title
An Examination of Brain Abnormalities and Mobility in Individuals with Mild Cognitive Impairment and Alzheimer's Disease
Published in
Frontiers in Aging Neuroscience, April 2017
DOI 10.3389/fnagi.2017.00086
Pubmed ID
Authors

Barbara L. Fischer, Rhonda Bacher, Barbara B. Bendlin, Alex C. Birdsill, Martina Ly, Siobhan M. Hoscheidt, Richard J. Chappell, Jane E. Mahoney, Carey E. Gleason

Abstract

Background: Mobility changes are concerning for elderly patients with cognitive decline. Given frail older individuals' vulnerability to injury, it is critical to identify contributors to limited mobility. Objective: To examine whether structural brain abnormalities, including reduced gray matter volume and white matter hyperintensities, would be associated with limited mobility among individuals with cognitive impairment, and to determine whether cognitive impairment would mediate this relationship. Methods: Thirty-four elderly individuals with mild cognitive impairment (MCI) and Alzheimer's disease underwent neuropsychological evaluation, mobility assessment, and structural brain neuroimaging. Linear regression was conducted with predictors including gray matter volume in six regions of interest (ROI) and white matter hyperintensity (WMH) burden, with mobility measures as outcomes. Results: Lower gray matter volume in caudate nucleus was associated with slower speed on a functional mobility task. Higher cerebellar volume was also associated with slower functional mobility. White matter hyperintensity burden was not significantly associated with mobility. Conclusion: Our findings provide evidence for associations between subcortical gray matter volume and speed on a functional mobility task among cognitively impaired individuals.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 57 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 14%
Student > Master 8 14%
Student > Bachelor 8 14%
Student > Doctoral Student 4 7%
Student > Ph. D. Student 4 7%
Other 7 12%
Unknown 18 32%
Readers by discipline Count As %
Psychology 11 19%
Neuroscience 6 11%
Nursing and Health Professions 6 11%
Medicine and Dentistry 3 5%
Linguistics 3 5%
Other 7 12%
Unknown 21 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2017.
All research outputs
#2,657,086
of 22,963,381 outputs
Outputs from Frontiers in Aging Neuroscience
#985
of 4,832 outputs
Outputs of similar age
#51,277
of 309,563 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#41
of 116 outputs
Altmetric has tracked 22,963,381 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,832 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 309,563 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.