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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Premature Brain Aging in Baboons Resulting from Moderate Fetal Undernutrition
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, April 2017
|
| DOI | 10.3389/fnagi.2017.00092 |
| Pubmed ID | |
| Authors |
Katja Franke, Geoffrey D. Clarke, Robert Dahnke, Christian Gaser, Anderson H. Kuo, Cun Li, Matthias Schwab, Peter W. Nathanielsz |
| Abstract |
Contrary to the known benefits from a moderate dietary reduction during adulthood on life span and health, maternal nutrient reduction during pregnancy is supposed to affect the developing brain, probably resulting in impaired brain structure and function throughout life. Decreased fetal nutrition delivery is widespread in both developing and developed countries, caused by poverty and natural disasters, but also due to maternal dieting, teenage pregnancy, pregnancy in women over 35 years of age, placental insufficiency, or multiples. Compromised development of fetal cerebral structures was already shown in our baboon model of moderate maternal nutrient reduction. The present study was designed to follow-up and evaluate the effects of moderate maternal nutrient reduction on individual brain aging in the baboon during young adulthood (4-7 years; human equivalent 14-24 years), applying a novel, non-invasive neuroimaging aging biomarker. The study reveals premature brain aging of +2.7 years (p < 0.01) in the female baboon exposed to fetal undernutrition. The effects of moderate maternal nutrient reduction on individual brain aging occurred in the absence of fetal growth restriction or marked maternal weight reduction at birth, which stresses the significance of early nutritional conditions in life-long developmental programming. This non-invasive MRI biomarker allows further longitudinal in vivo tracking of individual brain aging trajectories to assess the life-long effects of developmental and environmental influences in programming paradigms, aiding preventive and curative treatments on cerebral atrophy in experimental animal models and humans. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 111 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 23% |
| Student > Master | 15 | 14% |
| Student > Bachelor | 13 | 12% |
| Researcher | 13 | 12% |
| Student > Doctoral Student | 5 | 5% |
| Other | 17 | 15% |
| Unknown | 22 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 17% |
| Neuroscience | 13 | 12% |
| Agricultural and Biological Sciences | 9 | 8% |
| Psychology | 7 | 6% |
| Computer Science | 7 | 6% |
| Other | 25 | 23% |
| Unknown | 31 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2017.
All research outputs
#17,886,132
of 22,965,074 outputs
Outputs from Frontiers in Aging Neuroscience
#3,826
of 4,833 outputs
Outputs of similar age
#221,349
of 310,118 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#106
of 121 outputs
Altmetric has tracked 22,965,074 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,833 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,118 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.