Title |
Reduced Prefrontal Short—Latency Afferent Inhibition in Older Adults and Its Relation to Executive Function: A TMS-EEG Study
|
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Published in |
Frontiers in Aging Neuroscience, May 2017
|
DOI | 10.3389/fnagi.2017.00119 |
Pubmed ID | |
Authors |
Yoshihiro Noda, Reza Zomorrodi, Felicity Backhouse, Robin F. H. Cash, Mera S. Barr, Tarek K. Rajji, Robert Chen, Zafiris J. Daskalakis, Daniel M. Blumberger |
Abstract |
Combining transcranial magnetic stimulation (TMS) with electroencephalography (EEG) allows for the assessment of various neurophysiological processes in the human cortex. One of these paradigms, short-latency afferent inhibition (SAI), is thought to be a sensitive measure of cholinergic activity. In a previous study, we demonstrated the temporal pattern of this paradigm from both the motor (M1) and dorsolateral prefrontal cortex (DLPFC) using simultaneous TMS-EEG recording. The SAI paradigm led to marked modulations at N100. In this study, we aimed to investigate the age-related effects on TMS-evoked potentials (TEPs) with the SAI from M1 and the DLPFC in younger (18-59 years old) and older (≥60 years old) participants. Older participants showed significantly lower N100 modulation in M1-SAI as well as DLPFC-SAI compared to the younger participants. Furthermore, the modulation of N100 by DLPFC-SAI in the older participants correlated with executive function as measured with the Trail making test. This paradigm has the potential to non-invasively identify cholinergic changes in cortical regions related to cognition in older participants. |
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