Title |
Neurodegeneration and the Circadian Clock
|
---|---|
Published in |
Frontiers in Aging Neuroscience, May 2017
|
DOI | 10.3389/fnagi.2017.00170 |
Pubmed ID | |
Authors |
Suzanne Hood, Shimon Amir |
Abstract |
Despite varied etiologies and symptoms, several neurodegenerative diseases-specifically, Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HDs)-share the common feature of abnormal circadian rhythms, such as those in behavior (e.g., disrupted sleep/wake cycles), physiological processes (e.g., diminished hormone release) and biochemical activities (e.g., antioxidant production). Circadian disturbances are among the earliest symptoms of these diseases, and the molecular mechanisms of the circadian system are suspected to play a pivotal, and possibly causal, role in their natural histories. Here, we review the common circadian abnormalities observed in ADs, PDs and HDs, and summarize the evidence that the molecular circadian clockwork directly influences the course of these disease states. On the basis of this research, we explore several circadian-oriented interventions proposed as treatments for these neurological disorders. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 21% |
Luxembourg | 1 | 4% |
Spain | 1 | 4% |
Germany | 1 | 4% |
Canada | 1 | 4% |
Unknown | 15 | 63% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 18 | 75% |
Scientists | 3 | 13% |
Practitioners (doctors, other healthcare professionals) | 2 | 8% |
Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
Germany | 1 | <1% |
Unknown | 199 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 31 | 15% |
Student > Ph. D. Student | 26 | 13% |
Student > Master | 21 | 10% |
Researcher | 18 | 9% |
Student > Doctoral Student | 13 | 6% |
Other | 32 | 16% |
Unknown | 60 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 32 | 16% |
Biochemistry, Genetics and Molecular Biology | 28 | 14% |
Medicine and Dentistry | 27 | 13% |
Agricultural and Biological Sciences | 18 | 9% |
Psychology | 7 | 3% |
Other | 22 | 11% |
Unknown | 67 | 33% |