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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Sex Differences in the Cognitive and Hippocampal Effects of Streptozotocin in an Animal Model of Sporadic AD
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, October 2017
|
| DOI | 10.3389/fnagi.2017.00347 |
| Pubmed ID | |
| Authors |
Jian Bao, Yacoubou A. R. Mahaman, Rong Liu, Jian-Zhi Wang, Zhiguo Zhang, Bin Zhang, Xiaochuan Wang |
| Abstract |
More than 95% of Alzheimer's disease (AD) belongs to sporadic AD (sAD), and related animal models are the important research tools for investigating the pathogenesis and developing new drugs for sAD. An intracerebroventricular infusion of streptozotocin (ICV-STZ) is commonly employed to generate sporadic AD animal model. Moreover, the potential impact of sex on brain function is now emphasized in the field of AD. However, whether sex differences exist in AD animal models remains unknown. Here we reported that ICV-STZ remarkably resulted in learning and memory impairment in the Sprague-Dawley male rats, but not in the female rats. We also found tau hyperphosphorylation, an increase of Aβ40/42 as well as increase in both GSK-3β and BACE1 activities, while a loss of dendritic and synaptic plasticity was observed in the male STZ rats. However, STZ did not induce above alterations in the female rats. Furthermore, estradiol levels of serum and hippocampus of female rats were much higher than that of male rats. In conclusion, sex differences exist in this sporadic AD animal model (Sprague-Dawley rats induced by STZ), and this should be considered in future AD research. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 61 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 16% |
| Student > Master | 7 | 11% |
| Student > Bachelor | 7 | 11% |
| Researcher | 5 | 8% |
| Professor | 4 | 7% |
| Other | 10 | 16% |
| Unknown | 18 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 23% |
| Medicine and Dentistry | 9 | 15% |
| Biochemistry, Genetics and Molecular Biology | 5 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
| Psychology | 3 | 5% |
| Other | 5 | 8% |
| Unknown | 21 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2017.
All research outputs
#20,451,991
of 23,007,887 outputs
Outputs from Frontiers in Aging Neuroscience
#4,340
of 4,843 outputs
Outputs of similar age
#286,643
of 328,934 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#93
of 110 outputs
Altmetric has tracked 23,007,887 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,843 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.