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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Complement System Is Critical in Maintaining Retinal Integrity during Aging
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, February 2018
|
| DOI | 10.3389/fnagi.2018.00015 |
| Pubmed ID | |
| Authors |
Ryo Mukai, Yoko Okunuki, Deeba Husain, Clifford B. Kim, John D. Lambris, Kip M. Connor |
| Abstract |
The complement system is a key component of innate immunity comprised of soluble components that form a proteolytic cascade leading to the generation of effector molecules involved in cellular clearance. This system is highly activated not only under general inflammatory conditions such as infections, collagen diseases, nephritis, and liver diseases, but also in focal ocular diseases. However, little is known about the role of the complement system in retinal homeostasis during aging. Using young (6-week-old) and adult (6-month-old) mice in wild type (C57BL/6) and complement knockout strains (C1q-/-,Mbl a/c-/-,Fb-/-,C3-/-, andC5-/-), we compared amplitudes of electroretinograms (ERG) and thicknesses of retinal layers in spectral domain optical coherence tomography between young and adult mice. The ERG amplitudes in adult mice were significantly decreased (p< 0.001,p< 0.0001) compared to that of young mice in all complement knockout strains, and there were significant decreases in the inner nuclear layer (INL) thickness in adult mice compared to young mice in all complement knockout strains (p< 0.0001). There were no significant differences in ERG amplitude or thickness of the INL between young and adult control mice. These data suggest that the complement system plays an important role in maintaining normal retinal integrity over time. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 27% |
| Other | 5 | 10% |
| Professor | 3 | 6% |
| Professor > Associate Professor | 3 | 6% |
| Student > Doctoral Student | 2 | 4% |
| Other | 7 | 13% |
| Unknown | 18 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 19% |
| Medicine and Dentistry | 10 | 19% |
| Agricultural and Biological Sciences | 4 | 8% |
| Neuroscience | 4 | 8% |
| Engineering | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 19 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2023.
All research outputs
#3,239,422
of 26,329,145 outputs
Outputs from Frontiers in Aging Neuroscience
#1,281
of 5,673 outputs
Outputs of similar age
#73,670
of 476,961 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#30
of 108 outputs
Altmetric has tracked 26,329,145 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,673 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 476,961 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.