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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Plasma Amyloid Is Associated with White Matter and Subcortical Alterations and Is Modulated by Age and Seasonal Rhythms in Mouse Lemur Primates
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, February 2018
|
| DOI | 10.3389/fnagi.2018.00035 |
| Pubmed ID | |
| Authors |
Charlotte Gary, Anne-Sophie Hérard, Zoé Hanss, Marc Dhenain |
| Abstract |
Accumulation of amyloid-β (Aβ) peptides in the brain is a critical early event in the pathogenesis of Alzheimer's disease (AD), the most common age-related neurodegenerative disorder. There is increasing interest in measuring levels of plasma Aβ since this could help in diagnosis of brain pathology. However, the value of plasma Aβ in such a diagnosis is still controversial and factors modulating its levels are still poorly understood. The mouse lemur (Microcebus murinus) is a primate model of cerebral aging which can also present with amyloid plaques and whose Aβ is highly homologous to humans'. In an attempt to characterize this primate model and to evaluate the potential of plasma Aβ as a biomarker for brain alterations, we measured plasma Aβ40concentration in 21 animals aged from 5 to 9.5 years. We observed an age-related increase in plasma Aβ40levels. We then evaluated the relationships between plasma Aβ40levels and cerebral atrophy in these mouse lemurs. Voxel-based analysis of cerebral MR images (adjusted for the age/sex/brain size of the animals), showed that low Aβ40levels are associated with atrophy of several white matter and subcortical brain regions. These results suggest that low Aβ40levels in middle-aged/old animals are associated with brain deterioration. One special feature of mouse lemurs is that their metabolic and physiological parameters follow seasonal changes strictly controlled by illumination. We evaluated seasonal-related variations of plasma Aβ40levels and found a strong effect, with higher plasma Aβ40concentrations in winter conditions compared to summer. This question of seasonal modulation of Aβ plasma levels should be addressed in clinical studies. We also focused on the amplitude of the difference between plasma Aβ40levels during the two seasons and found that this amplitude increases with age. Possible mechanisms leading to these seasonal changes are discussed. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Switzerland | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 25% |
| Student > Ph. D. Student | 5 | 21% |
| Student > Bachelor | 3 | 13% |
| Lecturer | 1 | 4% |
| Student > Doctoral Student | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 8 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 7 | 29% |
| Agricultural and Biological Sciences | 3 | 13% |
| Chemical Engineering | 1 | 4% |
| Psychology | 1 | 4% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 9 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2018.
All research outputs
#13,580,944
of 23,023,224 outputs
Outputs from Frontiers in Aging Neuroscience
#2,996
of 4,846 outputs
Outputs of similar age
#223,792
of 446,257 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#72
of 108 outputs
Altmetric has tracked 23,023,224 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,846 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,257 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.